TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1706A/-:
none

Correlation of Rv1706A/- with Rv1706A/-

Normalized LFCs for Rv1706A/-:
(description and provenance of datasets)

	Rv1706A/-	Rv1706A/-
Fe_supp_jason_reseq	2.565	2.565
low_pH_jason_reseq	-3.736	-3.736
NO_jason_reseq	0.31	0.31
B6_jason_reseq	-2.478	-2.478
MHCII_jason_reseq	-2.182	-2.182
Isoniazid02	1.081	1.081
Rifampicin4	-0.958	-0.958
Ethambutol3	0.146	0.146
Meropenem3	-0.654	-0.654
Vancomycin16	0.318	0.318
Rv2680_day32	-0.081	-0.081
H37Rv_KO_MarP	-1.174	-1.174
hypoxia_3wks	-0.885	-0.885
hypoxia_6wks	-0.727	-0.727
glycerol	0.0	0.0
cholesterol	0.0	0.0
AJ	0.0	0.0
Bibs02	0.0	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	0.198	0.198
BXD01	0.0	0.0
BXD010	0.244	0.244
BXD011	1.22	1.22
BXD03	2.217	2.217
BXD04	0.0	0.0
BXD05	0.0	0.0
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.365	0.365
BXD09	2.142	2.142
CAST	0.976	0.976
CCcont	1.082	1.082
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.0	0.0
DS0c	0.0	0.0
GP01	2.079	2.079
GP02	0.603	0.603
GP0c	4.658	4.658
NOD	0.0	0.0
NZO	0.199	0.199
PWK	0.0	0.0
H37Rv_KO_CtpC	1.686	1.686
H37Rv_KO_CtpD	0.537	0.537
H37Rv_KO_Rv1272	3.802	3.802
H37Rv_KO_SugABC	0.0	0.0
H37Rv_KO_MbtN	0.85	0.85
Trans05	1.077	1.077
macrophage_unactivated	-2.326	-2.326
IL1	-1.528	-1.528
Rapamycin	-0.988	-0.988
Tcell	2.353	2.353
GMCSF	3.335	3.335
IFNab	0.0	0.0
IFNg	3.608	3.608
IFNg_GMCSF1	6.0	6.0
Rv1432_day32	-0.495	-0.495
Rv1565c_day32	0.599	0.599
secA2_input	-2.915	-2.915
delta_Rv3594	2.867	2.867
delta_Rv3717	2.771	2.771
delta_Rv3811	2.357	2.357
delta_Rv0954	3.982	3.982
PonA1	2.005	2.005
EccD1_KO	-1.388	-1.388
EspI_KO	-2.795	-2.795
PE35_KO	-0.852	-0.852
PPE68_KO	0.832	0.832
glycerol2	0.193	0.193
lignocerate	0.826	0.826
oleate	0.196	0.196
phosphatidylcholine	0.0	0.0
acetate	2.553	2.553
glucAc	1.868	1.868
Rv0950ko	1.221	1.221
Rv1096ko	1.562	1.562
Rv3684ko	1.608	1.608
delta_otsA_trehalose	0.0	0.0