TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1699/pyrG:
none

Correlation of Rv1699/pyrG with Rv1699/pyrG

Normalized LFCs for Rv1699/pyrG:
(description and provenance of datasets)

	Rv1699/pyrG	Rv1699/pyrG
Fe_supp_jason_reseq	1.07	1.07
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	0.0	0.0
Rifampicin4	0.0	0.0
Ethambutol3	0.0	0.0
Meropenem3	0.0	0.0
Vancomycin16	0.0	0.0
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	-0.195	-0.195
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	0.0	0.0
cholesterol	0.0	0.0
AJ	0.0	0.0
Bibs02	0.0	0.0
Bibs02c	0.209	0.209
BL6	0.0	0.0
BL6a	0.198	0.198
BXD01	0.0	0.0
BXD010	0.244	0.244
BXD011	0.127	0.127
BXD03	0.0	0.0
BXD04	0.124	0.124
BXD05	0.135	0.135
BXD06	0.0	0.0
BXD07	0.264	0.264
BXD08	0.253	0.253
BXD09	0.14	0.14
CAST	0.0	0.0
CCcont	0.285	0.285
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.194	0.194
DS0c	0.0	0.0
GP01	0.0	0.0
GP02	0.0	0.0
GP0c	0.13	0.13
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.0	0.0
H37Rv_KO_CtpD	0.0	0.0
H37Rv_KO_Rv1272	0.598	0.598
H37Rv_KO_SugABC	0.099	0.099
H37Rv_KO_MbtN	0.0	0.0
Trans05	0.0	0.0
macrophage_unactivated	0.701	0.701
IL1	0.0	0.0
Rapamycin	0.353	0.353
Tcell	-0.411	-0.411
GMCSF	0.304	0.304
IFNab	-0.381	-0.381
IFNg	0.0	0.0
IFNg_GMCSF1	0.361	0.361
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.449	0.449
secA2_input	0.412	0.412
delta_Rv3594	0.0	0.0
delta_Rv3717	0.0	0.0
delta_Rv3811	0.0	0.0
delta_Rv0954	0.178	0.178
PonA1	0.304	0.304
EccD1_KO	0.0	0.0
EspI_KO	0.394	0.394
PE35_KO	0.767	0.767
PPE68_KO	0.442	0.442
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	0.0	0.0
Rv1096ko	0.416	0.416
Rv3684ko	0.452	0.452
delta_otsA_trehalose	0.0	0.0