TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1572c/-:
none

Correlation of Rv1572c/- with Rv1572c/-

Normalized LFCs for Rv1572c/-:
(description and provenance of datasets)

	Rv1572c/-	Rv1572c/-
Fe_supp_jason_reseq	0.47	0.47
low_pH_jason_reseq	2.515	2.515
NO_jason_reseq	3.471	3.471
B6_jason_reseq	-2.511	-2.511
MHCII_jason_reseq	-2.212	-2.212
Isoniazid02	2.882	2.882
Rifampicin4	3.455	3.455
Ethambutol3	1.589	1.589
Meropenem3	2.727	2.727
Vancomycin16	4.765	4.765
Rv2680_day32	-1.366	-1.366
H37Rv_KO_MarP	-1.037	-1.037
hypoxia_3wks	0.375	0.375
hypoxia_6wks	0.363	0.363
glycerol	0.0	0.0
cholesterol	0.0	0.0
AJ	0.0	0.0
Bibs02	0.775	0.775
Bibs02c	0.0	0.0
BL6	2.023	2.023
BL6a	5.019	5.019
BXD01	2.848	2.848
BXD010	3.769	3.769
BXD011	4.496	4.496
BXD03	6.0	6.0
BXD04	3.447	3.447
BXD05	6.0	6.0
BXD06	3.419	3.419
BXD07	2.857	2.857
BXD08	4.491	4.491
BXD09	3.054	3.054
CAST	0.0	0.0
CCcont	1.231	1.231
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.682	0.682
DS0c	0.0	0.0
GP01	0.0	0.0
GP02	0.0	0.0
GP0c	0.0	0.0
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	3.926	3.926
H37Rv_KO_CtpD	1.159	1.159
H37Rv_KO_Rv1272	0.783	0.783
H37Rv_KO_SugABC	0.0	0.0
H37Rv_KO_MbtN	1.03	1.03
Trans05	1.787	1.787
macrophage_unactivated	-4.226	-4.226
IL1	0.116	0.116
Rapamycin	-0.092	-0.092
Tcell	-1.443	-1.443
GMCSF	1.267	1.267
IFNab	-0.423	-0.423
IFNg	-1.096	-1.096
IFNg_GMCSF1	0.691	0.691
Rv1432_day32	-0.34	-0.34
Rv1565c_day32	-0.945	-0.945
secA2_input	-1.293	-1.293
delta_Rv3594	0.265	0.265
delta_Rv3717	1.608	1.608
delta_Rv3811	2.857	2.857
delta_Rv0954	0.391	0.391
PonA1	1.805	1.805
EccD1_KO	2.763	2.763
EspI_KO	2.553	2.553
PE35_KO	1.581	1.581
PPE68_KO	1.267	1.267
glycerol2	-4.81	-4.81
lignocerate	-2.457	-2.457
oleate	-4.611	-4.611
phosphatidylcholine	-3.277	-3.277
acetate	-1.978	-1.978
glucAc	-2.202	-2.202
Rv0950ko	6.0	6.0
Rv1096ko	1.279	1.279
Rv3684ko	3.501	3.501
delta_otsA_trehalose	0.0	0.0