TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1508c/-:
none

Correlation of Rv1508c/- with Rv1508c/-

Normalized LFCs for Rv1508c/-:
(description and provenance of datasets)

	Rv1508c/-	Rv1508c/-
Fe_supp_jason_reseq	-0.568	-0.568
low_pH_jason_reseq	-0.539	-0.539
NO_jason_reseq	-0.092	-0.092
B6_jason_reseq	-0.468	-0.468
MHCII_jason_reseq	-0.512	-0.512
Isoniazid02	0.39	0.39
Rifampicin4	0.338	0.338
Ethambutol3	1.004	1.004
Meropenem3	-0.357	-0.357
Vancomycin16	-0.35	-0.35
Rv2680_day32	-0.124	-0.124
H37Rv_KO_MarP	0.016	0.016
hypoxia_3wks	0.215	0.215
hypoxia_6wks	0.37	0.37
glycerol	0.11	0.11
cholesterol	-0.227	-0.227
AJ	0.059	0.059
Bibs02	0.282	0.282
Bibs02c	-0.433	-0.433
BL6	0.879	0.879
BL6a	0.392	0.392
BXD01	0.561	0.561
BXD010	0.702	0.702
BXD011	1.037	1.037
BXD03	0.412	0.412
BXD04	0.236	0.236
BXD05	0.668	0.668
BXD06	0.681	0.681
BXD07	0.541	0.541
BXD08	0.463	0.463
BXD09	0.788	0.788
CAST	0.143	0.143
CCcont	0.306	0.306
DS01	-0.156	-0.156
DS02	-0.507	-0.507
DS04	0.112	0.112
DS0c	0.072	0.072
GP01	0.461	0.461
GP02	0.993	0.993
GP0c	0.033	0.033
NOD	1.079	1.079
NZO	0.603	0.603
PWK	0.604	0.604
H37Rv_KO_CtpC	0.5	0.5
H37Rv_KO_CtpD	0.682	0.682
H37Rv_KO_Rv1272	0.83	0.83
H37Rv_KO_SugABC	0.903	0.903
H37Rv_KO_MbtN	0.514	0.514
Trans05	0.23	0.23
macrophage_unactivated	-0.202	-0.202
IL1	-0.374	-0.374
Rapamycin	-0.012	-0.012
Tcell	0.31	0.31
GMCSF	0.127	0.127
IFNab	-0.366	-0.366
IFNg	0.048	0.048
IFNg_GMCSF1	-0.487	-0.487
Rv1432_day32	-0.085	-0.085
Rv1565c_day32	0.153	0.153
secA2_input	-0.457	-0.457
delta_Rv3594	-0.213	-0.213
delta_Rv3717	-0.321	-0.321
delta_Rv3811	-0.317	-0.317
delta_Rv0954	-0.194	-0.194
PonA1	-0.373	-0.373
EccD1_KO	0.112	0.112
EspI_KO	0.114	0.114
PE35_KO	0.496	0.496
PPE68_KO	0.339	0.339
glycerol2	0.265	0.265
lignocerate	0.701	0.701
oleate	0.367	0.367
phosphatidylcholine	0.703	0.703
acetate	0.475	0.475
glucAc	0.59	0.59
Rv0950ko	-0.057	-0.057
Rv1096ko	-0.856	-0.856
Rv3684ko	-0.763	-0.763
delta_otsA_trehalose	0.443	0.443