TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1485/hemZ:
none

Correlation of Rv1485/hemZ with Rv1485/hemZ

Normalized LFCs for Rv1485/hemZ:
(description and provenance of datasets)

	Rv1485/hemZ	Rv1485/hemZ
Fe_supp_jason_reseq	0.0	0.0
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	-0.351	-0.351
Rifampicin4	0.0	0.0
Ethambutol3	-0.14	-0.14
Meropenem3	-0.138	-0.138
Vancomycin16	-0.305	-0.305
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	0.0	0.0
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	-0.202	-0.202
cholesterol	-0.145	-0.145
AJ	-0.232	-0.232
Bibs02	-0.183	-0.183
Bibs02c	-0.209	-0.209
BL6	-0.125	-0.125
BL6a	-0.198	-0.198
BXD01	-0.13	-0.13
BXD010	-0.128	-0.128
BXD011	-0.127	-0.127
BXD03	-0.135	-0.135
BXD04	-0.124	-0.124
BXD05	-0.135	-0.135
BXD06	-0.133	-0.133
BXD07	-0.138	-0.138
BXD08	-0.133	-0.133
BXD09	-0.14	-0.14
CAST	-0.23	-0.23
CCcont	-0.149	-0.149
DS01	-0.236	-0.236
DS02	-0.217	-0.217
DS04	-0.194	-0.194
DS0c	-0.217	-0.217
GP01	-0.099	-0.099
GP02	-0.083	-0.083
GP0c	0.0	0.0
NOD	-0.225	-0.225
NZO	-0.199	-0.199
PWK	-0.196	-0.196
H37Rv_KO_CtpC	0.0	0.0
H37Rv_KO_CtpD	-0.127	-0.127
H37Rv_KO_Rv1272	-0.141	-0.141
H37Rv_KO_SugABC	-0.099	-0.099
H37Rv_KO_MbtN	-0.103	-0.103
Trans05	0.119	0.119
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-0.412	-0.412
delta_Rv3594	0.0	0.0
delta_Rv3717	0.0	0.0
delta_Rv3811	0.0	0.0
delta_Rv0954	0.0	0.0
PonA1	0.0	0.0
EccD1_KO	0.0	0.0
EspI_KO	0.0	0.0
PE35_KO	0.0	0.0
PPE68_KO	0.0	0.0
glycerol2	-0.193	-0.193
lignocerate	-0.168	-0.168
oleate	-0.196	-0.196
phosphatidylcholine	-0.193	-0.193
acetate	-0.229	-0.229
glucAc	-0.143	-0.143
Rv0950ko	0.0	0.0
Rv1096ko	0.0	0.0
Rv3684ko	0.452	0.452
delta_otsA_trehalose	0.0	0.0