TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1470/trxA:

update plot	correlation	link to info on gene
Rv2063/mazE7	(cc=0.5233)	info on Rv2063/mazE7
Rv1073/-	(cc=0.5228)	info on Rv1073/-
Rv2267c/-	(cc=0.5083)	info on Rv2267c/-
Rv2148c/-	(cc=0.4892)	info on Rv2148c/-
Rv2276/cyp121	(cc=0.4796)	info on Rv2276/cyp121
Rv2775/-	(cc=0.4633)	info on Rv2775/-
Rv1526c/-	(cc=0.4518)	info on Rv1526c/-
Rv1503c/-	(cc=0.4413)	info on Rv1503c/-
Rv3219/whiB1	(cc=0.4396)	info on Rv3219/whiB1
Rv3429/PPE59	(cc=0.4372)	info on Rv3429/PPE59

Correlation of Rv1470/trxA with Rv2063/mazE7

Normalized LFCs for Rv1470/trxA:
(description and provenance of datasets)

	Rv1470/trxA	Rv2063/mazE7
Fe_supp_jason_reseq	1.092	1.13
low_pH_jason_reseq	0.489	-0.51
NO_jason_reseq	-0.945	-1.402
B6_jason_reseq	-1.231	-2.297
MHCII_jason_reseq	-0.156	-2.023
Isoniazid02	-1.298	-0.762
Rifampicin4	-1.817	-0.087
Ethambutol3	-0.413	0.406
Meropenem3	0.423	-0.038
Vancomycin16	-1.645	0.241
Rv2680_day32	0.878	-0.131
H37Rv_KO_MarP	-0.089	-3.737
hypoxia_3wks	0.77	0.0
hypoxia_6wks	0.599	0.0
glycerol	-0.708	0.0
cholesterol	-0.723	0.0
AJ	0.281	0.0
Bibs02	-1.491	0.0
Bibs02c	-0.491	0.0
BL6	-0.014	0.0
BL6a	0.156	0.0
BXD01	0.347	0.0
BXD010	-1.012	0.0
BXD011	0.605	0.0
BXD03	0.36	0.0
BXD04	0.743	0.0
BXD05	0.322	0.135
BXD06	0.319	0.0
BXD07	-0.567	0.0
BXD08	0.47	0.0
BXD09	0.449	0.0
CAST	0.582	0.0
CCcont	1.09	0.0
DS01	0.371	0.0
DS02	1.404	0.0
DS04	1.307	1.077
DS0c	-0.707	0.0
GP01	0.54	0.548
GP02	2.014	1.289
GP0c	1.434	2.435
NOD	-0.12	0.0
NZO	0.373	0.0
PWK	1.145	0.0
H37Rv_KO_CtpC	1.918	0.0
H37Rv_KO_CtpD	1.378	0.127
H37Rv_KO_Rv1272	1.657	0.0
H37Rv_KO_SugABC	1.62	0.718
H37Rv_KO_MbtN	1.067	0.943
Trans05	1.394	0.0
macrophage_unactivated	0.603	0.0
IL1	-0.237	0.0
Rapamycin	0.107	0.0
Tcell	-0.163	0.0
GMCSF	0.422	0.0
IFNab	-0.716	0.417
IFNg	0.46	0.0
IFNg_GMCSF1	0.402	0.0
Rv1432_day32	0.494	1.358
Rv1565c_day32	-0.766	0.0
secA2_input	-0.316	-1.199
delta_Rv3594	-0.038	-0.349
delta_Rv3717	-0.038	-0.692
delta_Rv3811	-0.381	-3.028
delta_Rv0954	0.428	-1.16
PonA1	-0.379	-0.042
EccD1_KO	1.355	3.743
EspI_KO	2.11	3.149
PE35_KO	2.459	3.22
PPE68_KO	1.955	2.451
glycerol2	1.523	0.0
lignocerate	1.436	0.0
oleate	0.454	0.196
phosphatidylcholine	1.312	0.0
acetate	1.428	0.0
glucAc	1.166	0.0
Rv0950ko	0.724	1.616
Rv1096ko	-0.232	-0.706
Rv3684ko	-1.156	-1.359
delta_otsA_trehalose	1.503	0.0