TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1370c/-:

update plot	correlation	link to info on gene
Rv3381c/-	(cc=0.8699)	info on Rv3381c/-
Rv2648/-	(cc=0.8373)	info on Rv2648/-
Rv1757c/-	(cc=0.835)	info on Rv1757c/-
Rv3325/-	(cc=0.8091)	info on Rv3325/-
Rv0795/-	(cc=0.7932)	info on Rv0795/-
Rv3474/-	(cc=0.7878)	info on Rv3474/-
Rv2105/-	(cc=0.7844)	info on Rv2105/-
Rv1763/-	(cc=0.7789)	info on Rv1763/-
Rv2815c/-	(cc=0.7646)	info on Rv2815c/-
Rv2168c/-	(cc=0.7612)	info on Rv2168c/-

Correlation of Rv1370c/- with Rv3381c/-

Normalized LFCs for Rv1370c/-:
(description and provenance of datasets)

	Rv1370c/-	Rv3381c/-
Fe_supp_jason_reseq	-0.051	0.027
low_pH_jason_reseq	0.636	0.413
NO_jason_reseq	-0.1	0.137
B6_jason_reseq	-0.233	-0.307
MHCII_jason_reseq	-0.533	0.322
Isoniazid02	0.029	-0.191
Rifampicin4	0.544	0.068
Ethambutol3	1.021	1.231
Meropenem3	-0.074	-0.375
Vancomycin16	0.0	-0.066
Rv2680_day32	-0.111	0.005
H37Rv_KO_MarP	-0.061	-0.234
hypoxia_3wks	0.961	0.865
hypoxia_6wks	-0.24	0.0
glycerol	-0.78	-0.654
cholesterol	-0.044	-0.163
AJ	1.22	1.198
Bibs02	-0.405	0.102
Bibs02c	0.868	0.9
BL6	-0.691	-0.594
BL6a	0.09	0.37
BXD01	0.086	-0.016
BXD010	0.201	0.163
BXD011	0.099	-0.021
BXD03	0.336	0.096
BXD04	0.116	-0.263
BXD05	0.52	0.332
BXD06	0.022	0.121
BXD07	0.223	0.221
BXD08	-0.006	-0.131
BXD09	0.075	-0.314
CAST	0.699	0.649
CCcont	-0.902	-0.727
DS01	0.371	0.696
DS02	0.302	0.627
DS04	0.333	0.559
DS0c	0.325	1.105
GP01	0.964	0.821
GP02	1.089	1.283
GP0c	0.279	0.175
NOD	0.156	0.295
NZO	0.816	1.045
PWK	1.434	1.38
H37Rv_KO_CtpC	0.354	0.542
H37Rv_KO_CtpD	0.063	0.184
H37Rv_KO_Rv1272	0.115	-0.139
H37Rv_KO_SugABC	0.156	-0.206
H37Rv_KO_MbtN	0.918	0.939
Trans05	0.355	0.348
macrophage_unactivated	-0.524	-1.001
IL1	-1.453	-1.166
Rapamycin	-0.537	-0.608
Tcell	-0.899	-1.916
GMCSF	0.021	-0.504
IFNab	-0.834	-1.11
IFNg	-0.66	-0.847
IFNg_GMCSF1	0.217	0.082
Rv1432_day32	1.219	1.245
Rv1565c_day32	-0.618	-0.322
secA2_input	0.632	-0.127
delta_Rv3594	-0.06	-0.047
delta_Rv3717	-0.342	-0.262
delta_Rv3811	-0.546	-0.352
delta_Rv0954	0.15	-0.063
PonA1	-0.89	-0.871
EccD1_KO	-0.243	-0.539
EspI_KO	0.836	0.887
PE35_KO	0.767	0.744
PPE68_KO	-0.339	0.435
glycerol2	-0.619	0.284
lignocerate	-0.203	0.118
oleate	-0.391	0.149
phosphatidylcholine	-0.303	0.228
acetate	1.405	2.045
glucAc	1.746	2.18
Rv0950ko	0.772	0.332
Rv1096ko	0.072	0.274
Rv3684ko	-0.039	0.016
delta_otsA_trehalose	0.517	0.201