TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1241/vapB33:
none

Correlation of Rv1241/vapB33 with Rv1241/vapB33

Normalized LFCs for Rv1241/vapB33:
(description and provenance of datasets)

	Rv1241/vapB33	Rv1241/vapB33
Fe_supp_jason_reseq	-1.52	-1.52
low_pH_jason_reseq	-1.375	-1.375
NO_jason_reseq	0.289	0.289
B6_jason_reseq	-0.326	-0.326
MHCII_jason_reseq	-2.86	-2.86
Isoniazid02	0.362	0.362
Rifampicin4	-0.46	-0.46
Ethambutol3	0.088	0.088
Meropenem3	0.114	0.114
Vancomycin16	0.491	0.491
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	1.029	1.029
hypoxia_3wks	-1.156	-1.156
hypoxia_6wks	-1.871	-1.871
glycerol	-3.011	-3.011
cholesterol	-1.446	-1.446
AJ	-0.156	-0.156
Bibs02	-3.974	-3.974
Bibs02c	2.016	2.016
BL6	-0.15	-0.15
BL6a	1.393	1.393
BXD01	-2.209	-2.209
BXD010	-3.86	-3.86
BXD011	-1.917	-1.917
BXD03	-2.798	-2.798
BXD04	-3.336	-3.336
BXD05	-4.433	-4.433
BXD06	-1.898	-1.898
BXD07	-1.471	-1.471
BXD08	-2.482	-2.482
BXD09	-2.593	-2.593
CAST	-0.996	-0.996
CCcont	-1.326	-1.326
DS01	-3.555	-3.555
DS02	-0.17	-0.17
DS04	-0.565	-0.565
DS0c	0.954	0.954
GP01	-3.523	-3.523
GP02	-2.969	-2.969
GP0c	-4.64	-4.64
NOD	-1.282	-1.282
NZO	-0.683	-0.683
PWK	2.397	2.397
H37Rv_KO_CtpC	-2.997	-2.997
H37Rv_KO_CtpD	-3.817	-3.817
H37Rv_KO_Rv1272	-0.805	-0.805
H37Rv_KO_SugABC	-2.767	-2.767
H37Rv_KO_MbtN	-3.678	-3.678
Trans05	-3.411	-3.411
macrophage_unactivated	-0.707	-0.707
IL1	-1.189	-1.189
Rapamycin	-1.531	-1.531
Tcell	-1.333	-1.333
GMCSF	-1.405	-1.405
IFNab	-2.936	-2.936
IFNg	-1.355	-1.355
IFNg_GMCSF1	-4.71	-4.71
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-5.554	-5.554
delta_Rv3594	0.0	0.0
delta_Rv3717	3.453	3.453
delta_Rv3811	3.179	3.179
delta_Rv0954	3.989	3.989
PonA1	3.992	3.992
EccD1_KO	0.25	0.25
EspI_KO	2.795	2.795
PE35_KO	-0.356	-0.356
PPE68_KO	-2.4	-2.4
glycerol2	0.68	0.68
lignocerate	2.151	2.151
oleate	0.0	0.0
phosphatidylcholine	0.679	0.679
acetate	5.017	5.017
glucAc	2.944	2.944
Rv0950ko	-2.204	-2.204
Rv1096ko	-0.618	-0.618
Rv3684ko	-4.081	-4.081
delta_otsA_trehalose	0.0	0.0