TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1222/rseA:
none

Correlation of Rv1222/rseA with Rv1222/rseA

Normalized LFCs for Rv1222/rseA:
(description and provenance of datasets)

	Rv1222/rseA	Rv1222/rseA
Fe_supp_jason_reseq	0.759	0.759
low_pH_jason_reseq	-0.38	-0.38
NO_jason_reseq	-0.047	-0.047
B6_jason_reseq	2.729	2.729
MHCII_jason_reseq	1.74	1.74
Isoniazid02	-0.902	-0.902
Rifampicin4	-1.784	-1.784
Ethambutol3	-0.337	-0.337
Meropenem3	-1.046	-1.046
Vancomycin16	-0.615	-0.615
Rv2680_day32	-1.267	-1.267
H37Rv_KO_MarP	-1.451	-1.451
hypoxia_3wks	0.355	0.355
hypoxia_6wks	2.445	2.445
glycerol	-2.121	-2.121
cholesterol	-1.097	-1.097
AJ	2.178	2.178
Bibs02	-0.303	-0.303
Bibs02c	-1.72	-1.72
BL6	0.718	0.718
BL6a	0.443	0.443
BXD01	1.261	1.261
BXD010	1.475	1.475
BXD011	0.454	0.454
BXD03	1.189	1.189
BXD04	1.411	1.411
BXD05	0.758	0.758
BXD06	0.973	0.973
BXD07	0.666	0.666
BXD08	1.794	1.794
BXD09	-0.052	-0.052
CAST	3.782	3.782
CCcont	-0.014	-0.014
DS01	-1.41	-1.41
DS02	-1.731	-1.731
DS04	1.154	1.154
DS0c	0.229	0.229
GP01	-1.476	-1.476
GP02	-1.796	-1.796
GP0c	0.432	0.432
NOD	1.333	1.333
NZO	1.761	1.761
PWK	4.284	4.284
H37Rv_KO_CtpC	2.115	2.115
H37Rv_KO_CtpD	-1.831	-1.831
H37Rv_KO_Rv1272	0.757	0.757
H37Rv_KO_SugABC	1.985	1.985
H37Rv_KO_MbtN	-0.178	-0.178
Trans05	0.399	0.399
macrophage_unactivated	-0.489	-0.489
IL1	-1.984	-1.984
Rapamycin	-1.519	-1.519
Tcell	1.088	1.088
GMCSF	-0.457	-0.457
IFNab	-1.681	-1.681
IFNg	-0.855	-0.855
IFNg_GMCSF1	0.119	0.119
Rv1432_day32	0.991	0.991
Rv1565c_day32	-2.551	-2.551
secA2_input	-1.497	-1.497
delta_Rv3594	-0.309	-0.309
delta_Rv3717	-3.22	-3.22
delta_Rv3811	-1.5	-1.5
delta_Rv0954	-2.328	-2.328
PonA1	-1.547	-1.547
EccD1_KO	1.427	1.427
EspI_KO	0.585	0.585
PE35_KO	-0.732	-0.732
PPE68_KO	-1.776	-1.776
glycerol2	-1.487	-1.487
lignocerate	-1.062	-1.062
oleate	-0.696	-0.696
phosphatidylcholine	-1.221	-1.221
acetate	-0.417	-0.417
glucAc	0.147	0.147
Rv0950ko	1.11	1.11
Rv1096ko	1.957	1.957
Rv3684ko	2.397	2.397
delta_otsA_trehalose	-1.253	-1.253