TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1179c/-:
none

Correlation of Rv1179c/- with Rv1179c/-

Normalized LFCs for Rv1179c/-:
(description and provenance of datasets)

	Rv1179c/-	Rv1179c/-
Fe_supp_jason_reseq	-0.052	-0.052
low_pH_jason_reseq	-0.375	-0.375
NO_jason_reseq	-0.236	-0.236
B6_jason_reseq	1.437	1.437
MHCII_jason_reseq	1.03	1.03
Isoniazid02	0.608	0.608
Rifampicin4	0.095	0.095
Ethambutol3	0.603	0.603
Meropenem3	0.357	0.357
Vancomycin16	0.443	0.443
Rv2680_day32	0.285	0.285
H37Rv_KO_MarP	0.577	0.577
hypoxia_3wks	-0.04	-0.04
hypoxia_6wks	0.315	0.315
glycerol	-0.012	-0.012
cholesterol	0.238	0.238
AJ	0.052	0.052
Bibs02	0.199	0.199
Bibs02c	0.355	0.355
BL6	0.224	0.224
BL6a	-0.105	-0.105
BXD01	-0.263	-0.263
BXD010	-0.361	-0.361
BXD011	-0.418	-0.418
BXD03	-0.36	-0.36
BXD04	0.035	0.035
BXD05	-0.071	-0.071
BXD06	-0.524	-0.524
BXD07	-0.27	-0.27
BXD08	0.06	0.06
BXD09	-0.334	-0.334
CAST	0.434	0.434
CCcont	-0.421	-0.421
DS01	0.566	0.566
DS02	0.249	0.249
DS04	0.739	0.739
DS0c	0.52	0.52
GP01	0.372	0.372
GP02	-0.266	-0.266
GP0c	-0.337	-0.337
NOD	-0.078	-0.078
NZO	0.111	0.111
PWK	0.203	0.203
H37Rv_KO_CtpC	-0.086	-0.086
H37Rv_KO_CtpD	-0.221	-0.221
H37Rv_KO_Rv1272	-0.266	-0.266
H37Rv_KO_SugABC	0.493	0.493
H37Rv_KO_MbtN	-0.422	-0.422
Trans05	-0.255	-0.255
macrophage_unactivated	-0.224	-0.224
IL1	-0.181	-0.181
Rapamycin	-0.252	-0.252
Tcell	0.065	0.065
GMCSF	-0.106	-0.106
IFNab	-0.06	-0.06
IFNg	-0.053	-0.053
IFNg_GMCSF1	0.123	0.123
Rv1432_day32	-0.125	-0.125
Rv1565c_day32	-0.474	-0.474
secA2_input	0.233	0.233
delta_Rv3594	-0.017	-0.017
delta_Rv3717	-0.268	-0.268
delta_Rv3811	-0.558	-0.558
delta_Rv0954	0.214	0.214
PonA1	0.259	0.259
EccD1_KO	-0.174	-0.174
EspI_KO	-0.231	-0.231
PE35_KO	0.225	0.225
PPE68_KO	-0.17	-0.17
glycerol2	-0.154	-0.154
lignocerate	0.349	0.349
oleate	-0.309	-0.309
phosphatidylcholine	0.346	0.346
acetate	0.17	0.17
glucAc	0.229	0.229
Rv0950ko	1.046	1.046
Rv1096ko	0.778	0.778
Rv3684ko	0.298	0.298
delta_otsA_trehalose	0.965	0.965