TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1175c/fadH:

update plot	correlation	link to info on gene
Rv2345/-	(cc=0.5897)	info on Rv2345/-
Rv2068c/blaC	(cc=0.5489)	info on Rv2068c/blaC
Rv0605/-	(cc=0.488)	info on Rv0605/-
Rv2634c/PE_PGRS46	(cc=0.4844)	info on Rv2634c/PE_PGRS46
Rv0399c/lpqK	(cc=0.4744)	info on Rv0399c/lpqK
Rv2954c/-	(cc=0.4701)	info on Rv2954c/-
Rv1812c/-	(cc=0.4642)	info on Rv1812c/-
Rv2788/sirR	(cc=0.4597)	info on Rv2788/sirR
Rv0968/-	(cc=0.4423)	info on Rv0968/-
Rv1997/ctpF	(cc=0.4412)	info on Rv1997/ctpF

Correlation of Rv1175c/fadH with Rv2345/-

Normalized LFCs for Rv1175c/fadH:
(description and provenance of datasets)

	Rv1175c/fadH	Rv2345/-
Fe_supp_jason_reseq	-0.78	-0.019
low_pH_jason_reseq	-0.489	-0.962
NO_jason_reseq	-0.452	-0.053
B6_jason_reseq	-0.548	-0.063
MHCII_jason_reseq	-0.009	0.065
Isoniazid02	-0.784	-1.199
Rifampicin4	0.401	0.509
Ethambutol3	-0.703	-1.019
Meropenem3	-1.731	-1.409
Vancomycin16	-0.629	-0.655
Rv2680_day32	-0.947	-0.466
H37Rv_KO_MarP	0.13	-0.02
hypoxia_3wks	0.658	0.032
hypoxia_6wks	-0.088	0.257
glycerol	0.015	0.192
cholesterol	0.273	-0.086
AJ	-0.279	0.0
Bibs02	-0.191	-0.278
Bibs02c	-0.155	-0.205
BL6	0.0	0.138
BL6a	-0.043	0.118
BXD01	-0.445	0.14
BXD010	-0.046	0.141
BXD011	0.178	-0.262
BXD03	0.111	-0.04
BXD04	0.0	0.291
BXD05	0.488	0.374
BXD06	-0.307	0.147
BXD07	-0.246	0.238
BXD08	-0.429	0.434
BXD09	0.257	0.199
CAST	0.174	-0.225
CCcont	-0.121	0.024
DS01	-0.342	0.0
DS02	-0.128	-0.498
DS04	-0.429	-0.142
DS0c	-0.176	-0.057
GP01	0.125	0.277
GP02	-0.992	0.072
GP0c	-0.76	0.147
NOD	-0.148	0.265
NZO	-0.803	-0.237
PWK	-0.503	-0.058
H37Rv_KO_CtpC	-0.071	0.373
H37Rv_KO_CtpD	1.533	0.605
H37Rv_KO_Rv1272	0.161	0.291
H37Rv_KO_SugABC	0.1	0.767
H37Rv_KO_MbtN	-0.108	0.628
Trans05	0.474	0.501
macrophage_unactivated	0.379	-0.114
IL1	-0.163	0.338
Rapamycin	0.239	0.473
Tcell	0.391	0.039
GMCSF	0.488	0.599
IFNab	-0.166	0.311
IFNg	0.142	0.216
IFNg_GMCSF1	0.245	0.182
Rv1432_day32	-0.017	0.194
Rv1565c_day32	-0.011	0.175
secA2_input	0.214	0.233
delta_Rv3594	-0.041	0.271
delta_Rv3717	-0.214	0.055
delta_Rv3811	-0.297	0.352
delta_Rv0954	0.287	0.371
PonA1	-0.031	-0.321
EccD1_KO	0.793	0.704
EspI_KO	0.0	0.767
PE35_KO	0.79	0.429
PPE68_KO	0.294	0.176
glycerol2	0.615	0.277
lignocerate	0.789	0.284
oleate	0.077	0.702
phosphatidylcholine	0.727	0.153
acetate	0.068	-0.462
glucAc	0.124	-0.232
Rv0950ko	-0.057	0.434
Rv1096ko	-0.329	-0.567
Rv3684ko	-0.095	-0.54
delta_otsA_trehalose	0.42	0.582