TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1161/narG:
none

Correlation of Rv1161/narG with Rv1161/narG

Normalized LFCs for Rv1161/narG:
(description and provenance of datasets)

	Rv1161/narG	Rv1161/narG
Fe_supp_jason_reseq	-0.14	-0.14
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.11	0.11
B6_jason_reseq	-0.361	-0.361
MHCII_jason_reseq	0.44	0.44
Isoniazid02	-0.784	-0.784
Rifampicin4	0.171	0.171
Ethambutol3	-0.272	-0.272
Meropenem3	-0.55	-0.55
Vancomycin16	-0.337	-0.337
Rv2680_day32	-0.168	-0.168
H37Rv_KO_MarP	0.518	0.518
hypoxia_3wks	0.04	0.04
hypoxia_6wks	-0.167	-0.167
glycerol	0.404	0.404
cholesterol	0.282	0.282
AJ	0.103	0.103
Bibs02	0.605	0.605
Bibs02c	0.303	0.303
BL6	-0.23	-0.23
BL6a	0.265	0.265
BXD01	-0.106	-0.106
BXD010	-0.256	-0.256
BXD011	0.041	0.041
BXD03	0.134	0.134
BXD04	-0.024	-0.024
BXD05	-0.026	-0.026
BXD06	-0.108	-0.108
BXD07	0.277	0.277
BXD08	-0.035	-0.035
BXD09	0.188	0.188
CAST	-0.092	-0.092
CCcont	-0.196	-0.196
DS01	0.178	0.178
DS02	0.55	0.55
DS04	1.1	1.1
DS0c	0.339	0.339
GP01	-0.129	-0.129
GP02	-0.496	-0.496
GP0c	-0.506	-0.506
NOD	0.877	0.877
NZO	-0.204	-0.204
PWK	-0.026	-0.026
H37Rv_KO_CtpC	0.152	0.152
H37Rv_KO_CtpD	0.095	0.095
H37Rv_KO_Rv1272	0.164	0.164
H37Rv_KO_SugABC	0.155	0.155
H37Rv_KO_MbtN	-0.676	-0.676
Trans05	-0.413	-0.413
macrophage_unactivated	0.215	0.215
IL1	0.685	0.685
Rapamycin	0.93	0.93
Tcell	-0.505	-0.505
GMCSF	0.98	0.98
IFNab	0.0	0.0
IFNg	-0.166	-0.166
IFNg_GMCSF1	-0.028	-0.028
Rv1432_day32	0.452	0.452
Rv1565c_day32	0.204	0.204
secA2_input	-0.684	-0.684
delta_Rv3594	-0.112	-0.112
delta_Rv3717	-0.599	-0.599
delta_Rv3811	-0.205	-0.205
delta_Rv0954	0.075	0.075
PonA1	0.067	0.067
EccD1_KO	-0.164	-0.164
EspI_KO	0.0	0.0
PE35_KO	0.07	0.07
PPE68_KO	0.154	0.154
glycerol2	0.188	0.188
lignocerate	0.486	0.486
oleate	0.699	0.699
phosphatidylcholine	0.678	0.678
acetate	0.145	0.145
glucAc	0.064	0.064
Rv0950ko	-0.241	-0.241
Rv1096ko	0.326	0.326
Rv3684ko	0.144	0.144
delta_otsA_trehalose	0.931	0.931