TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1154c/-:
none

Correlation of Rv1154c/- with Rv1154c/-

Normalized LFCs for Rv1154c/-:
(description and provenance of datasets)

	Rv1154c/-	Rv1154c/-
Fe_supp_jason_reseq	0.125	0.125
low_pH_jason_reseq	-0.52	-0.52
NO_jason_reseq	-0.281	-0.281
B6_jason_reseq	0.214	0.214
MHCII_jason_reseq	0.084	0.084
Isoniazid02	0.389	0.389
Rifampicin4	0.363	0.363
Ethambutol3	0.084	0.084
Meropenem3	0.337	0.337
Vancomycin16	-0.08	-0.08
Rv2680_day32	-0.367	-0.367
H37Rv_KO_MarP	0.391	0.391
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.223	0.223
glycerol	-0.87	-0.87
cholesterol	-0.007	-0.007
AJ	0.484	0.484
Bibs02	0.416	0.416
Bibs02c	0.437	0.437
BL6	-0.104	-0.104
BL6a	0.296	0.296
BXD01	0.401	0.401
BXD010	0.03	0.03
BXD011	0.355	0.355
BXD03	0.539	0.539
BXD04	0.469	0.469
BXD05	0.044	0.044
BXD06	0.368	0.368
BXD07	0.346	0.346
BXD08	0.747	0.747
BXD09	0.466	0.466
CAST	0.352	0.352
CCcont	-0.226	-0.226
DS01	0.01	0.01
DS02	0.6	0.6
DS04	-0.181	-0.181
DS0c	0.0	0.0
GP01	0.171	0.171
GP02	-0.587	-0.587
GP0c	0.1	0.1
NOD	1.069	1.069
NZO	0.171	0.171
PWK	0.276	0.276
H37Rv_KO_CtpC	0.594	0.594
H37Rv_KO_CtpD	-0.377	-0.377
H37Rv_KO_Rv1272	0.084	0.084
H37Rv_KO_SugABC	0.772	0.772
H37Rv_KO_MbtN	-0.244	-0.244
Trans05	0.512	0.512
macrophage_unactivated	-0.455	-0.455
IL1	-0.338	-0.338
Rapamycin	-0.424	-0.424
Tcell	-0.182	-0.182
GMCSF	-0.364	-0.364
IFNab	-0.381	-0.381
IFNg	-0.385	-0.385
IFNg_GMCSF1	-0.302	-0.302
Rv1432_day32	0.477	0.477
Rv1565c_day32	-0.093	-0.093
secA2_input	0.266	0.266
delta_Rv3594	-0.028	-0.028
delta_Rv3717	-0.328	-0.328
delta_Rv3811	0.039	0.039
delta_Rv0954	0.885	0.885
PonA1	-0.105	-0.105
EccD1_KO	0.46	0.46
EspI_KO	0.442	0.442
PE35_KO	-0.403	-0.403
PPE68_KO	0.102	0.102
glycerol2	-0.333	-0.333
lignocerate	-0.262	-0.262
oleate	-0.132	-0.132
phosphatidylcholine	-0.049	-0.049
acetate	-0.871	-0.871
glucAc	-0.572	-0.572
Rv0950ko	-0.338	-0.338
Rv1096ko	0.232	0.232
Rv3684ko	-0.707	-0.707
delta_otsA_trehalose	0.049	0.049