TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1146/mmpL13b:
none

Correlation of Rv1146/mmpL13b with Rv1146/mmpL13b

Normalized LFCs for Rv1146/mmpL13b:
(description and provenance of datasets)

	Rv1146/mmpL13b	Rv1146/mmpL13b
Fe_supp_jason_reseq	-0.134	-0.134
low_pH_jason_reseq	-0.308	-0.308
NO_jason_reseq	0.27	0.27
B6_jason_reseq	0.374	0.374
MHCII_jason_reseq	0.566	0.566
Isoniazid02	-0.38	-0.38
Rifampicin4	-0.152	-0.152
Ethambutol3	0.576	0.576
Meropenem3	0.14	0.14
Vancomycin16	-0.17	-0.17
Rv2680_day32	0.301	0.301
H37Rv_KO_MarP	0.058	0.058
hypoxia_3wks	0.187	0.187
hypoxia_6wks	0.142	0.142
glycerol	0.061	0.061
cholesterol	0.428	0.428
AJ	0.151	0.151
Bibs02	0.208	0.208
Bibs02c	0.473	0.473
BL6	0.305	0.305
BL6a	0.221	0.221
BXD01	-0.288	-0.288
BXD010	-0.168	-0.168
BXD011	0.063	0.063
BXD03	0.371	0.371
BXD04	0.103	0.103
BXD05	0.42	0.42
BXD06	-0.121	-0.121
BXD07	-0.117	-0.117
BXD08	0.239	0.239
BXD09	-0.081	-0.081
CAST	0.12	0.12
CCcont	-0.122	-0.122
DS01	0.539	0.539
DS02	0.611	0.611
DS04	0.686	0.686
DS0c	0.435	0.435
GP01	0.035	0.035
GP02	-0.747	-0.747
GP0c	0.046	0.046
NOD	0.228	0.228
NZO	0.692	0.692
PWK	-0.033	-0.033
H37Rv_KO_CtpC	0.009	0.009
H37Rv_KO_CtpD	1.097	1.097
H37Rv_KO_Rv1272	-0.428	-0.428
H37Rv_KO_SugABC	0.402	0.402
H37Rv_KO_MbtN	-0.22	-0.22
Trans05	0.014	0.014
macrophage_unactivated	-0.246	-0.246
IL1	0.056	0.056
Rapamycin	0.025	0.025
Tcell	-0.401	-0.401
GMCSF	-0.346	-0.346
IFNab	-0.248	-0.248
IFNg	0.091	0.091
IFNg_GMCSF1	0.094	0.094
Rv1432_day32	0.591	0.591
Rv1565c_day32	0.43	0.43
secA2_input	-0.33	-0.33
delta_Rv3594	-0.197	-0.197
delta_Rv3717	-0.272	-0.272
delta_Rv3811	-0.663	-0.663
delta_Rv0954	-0.32	-0.32
PonA1	0.294	0.294
EccD1_KO	0.868	0.868
EspI_KO	0.699	0.699
PE35_KO	0.356	0.356
PPE68_KO	0.541	0.541
glycerol2	0.492	0.492
lignocerate	0.744	0.744
oleate	0.363	0.363
phosphatidylcholine	0.546	0.546
acetate	0.073	0.073
glucAc	-0.024	-0.024
Rv0950ko	-0.211	-0.211
Rv1096ko	-0.407	-0.407
Rv3684ko	-0.141	-0.141
delta_otsA_trehalose	-0.603	-0.603