TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1137c/-:
none

Correlation of Rv1137c/- with Rv1137c/-

Normalized LFCs for Rv1137c/-:
(description and provenance of datasets)

	Rv1137c/-	Rv1137c/-
Fe_supp_jason_reseq	-0.437	-0.437
low_pH_jason_reseq	-1.765	-1.765
NO_jason_reseq	1.654	1.654
B6_jason_reseq	-4.137	-4.137
MHCII_jason_reseq	0.287	0.287
Isoniazid02	-0.329	-0.329
Rifampicin4	-0.612	-0.612
Ethambutol3	0.353	0.353
Meropenem3	0.774	0.774
Vancomycin16	-0.183	-0.183
Rv2680_day32	0.221	0.221
H37Rv_KO_MarP	-0.488	-0.488
hypoxia_3wks	-0.554	-0.554
hypoxia_6wks	-0.585	-0.585
glycerol	0.284	0.284
cholesterol	-0.152	-0.152
AJ	-0.281	-0.281
Bibs02	2.383	2.383
Bibs02c	-0.205	-0.205
BL6	2.289	2.289
BL6a	0.456	0.456
BXD01	1.348	1.348
BXD010	0.36	0.36
BXD011	2.548	2.548
BXD03	1.291	1.291
BXD04	1.03	1.03
BXD05	1.407	1.407
BXD06	1.967	1.967
BXD07	1.692	1.692
BXD08	2.091	2.091
BXD09	2.485	2.485
CAST	-0.574	-0.574
CCcont	1.459	1.459
DS01	-0.121	-0.121
DS02	-1.911	-1.911
DS04	0.638	0.638
DS0c	-1.667	-1.667
GP01	1.344	1.344
GP02	-0.401	-0.401
GP0c	0.918	0.918
NOD	-0.519	-0.519
NZO	-2.234	-2.234
PWK	-0.656	-0.656
H37Rv_KO_CtpC	1.575	1.575
H37Rv_KO_CtpD	-1.968	-1.968
H37Rv_KO_Rv1272	-0.031	-0.031
H37Rv_KO_SugABC	2.148	2.148
H37Rv_KO_MbtN	0.022	0.022
Trans05	-0.212	-0.212
macrophage_unactivated	0.518	0.518
IL1	-0.234	-0.234
Rapamycin	0.086	0.086
Tcell	-0.71	-0.71
GMCSF	-0.858	-0.858
IFNab	-0.505	-0.505
IFNg	0.735	0.735
IFNg_GMCSF1	-0.468	-0.468
Rv1432_day32	-2.151	-2.151
Rv1565c_day32	-0.036	-0.036
secA2_input	-2.049	-2.049
delta_Rv3594	0.194	0.194
delta_Rv3717	-0.618	-0.618
delta_Rv3811	0.26	0.26
delta_Rv0954	-0.699	-0.699
PonA1	-1.227	-1.227
EccD1_KO	0.109	0.109
EspI_KO	-0.231	-0.231
PE35_KO	-0.677	-0.677
PPE68_KO	-0.454	-0.454
glycerol2	0.453	0.453
lignocerate	0.83	0.83
oleate	0.427	0.427
phosphatidylcholine	1.169	1.169
acetate	0.045	0.045
glucAc	0.807	0.807
Rv0950ko	-2.005	-2.005
Rv1096ko	0.522	0.522
Rv3684ko	-0.262	-0.262
delta_otsA_trehalose	0.0	0.0