TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1113/vapB32:
none

Correlation of Rv1113/vapB32 with Rv1113/vapB32

Normalized LFCs for Rv1113/vapB32:
(description and provenance of datasets)

	Rv1113/vapB32	Rv1113/vapB32
Fe_supp_jason_reseq	-1.579	-1.579
low_pH_jason_reseq	0.328	0.328
NO_jason_reseq	-0.643	-0.643
B6_jason_reseq	-3.978	-3.978
MHCII_jason_reseq	-3.692	-3.692
Isoniazid02	-0.882	-0.882
Rifampicin4	-3.466	-3.466
Ethambutol3	-0.405	-0.405
Meropenem3	3.119	3.119
Vancomycin16	-0.979	-0.979
Rv2680_day32	-1.28	-1.28
H37Rv_KO_MarP	-0.754	-0.754
hypoxia_3wks	-1.049	-1.049
hypoxia_6wks	1.539	1.539
glycerol	-0.509	-0.509
cholesterol	0.105	0.105
AJ	0.866	0.866
Bibs02	1.256	1.256
Bibs02c	0.152	0.152
BL6	1.235	1.235
BL6a	3.474	3.474
BXD01	1.528	1.528
BXD010	1.301	1.301
BXD011	2.084	2.084
BXD03	1.65	1.65
BXD04	3.6	3.6
BXD05	3.638	3.638
BXD06	3.797	3.797
BXD07	2.558	2.558
BXD08	2.814	2.814
BXD09	3.783	3.783
CAST	-0.581	-0.581
CCcont	2.577	2.577
DS01	-0.83	-0.83
DS02	-0.764	-0.764
DS04	0.51	0.51
DS0c	0.44	0.44
GP01	0.946	0.946
GP02	0.469	0.469
GP0c	1.357	1.357
NOD	-0.789	-0.789
NZO	-0.503	-0.503
PWK	0.831	0.831
H37Rv_KO_CtpC	3.98	3.98
H37Rv_KO_CtpD	0.657	0.657
H37Rv_KO_Rv1272	0.451	0.451
H37Rv_KO_SugABC	-0.25	-0.25
H37Rv_KO_MbtN	-0.166	-0.166
Trans05	5.389	5.389
macrophage_unactivated	2.023	2.023
IL1	2.13	2.13
Rapamycin	3.093	3.093
Tcell	1.313	1.313
GMCSF	2.297	2.297
IFNab	1.908	1.908
IFNg	1.946	1.946
IFNg_GMCSF1	1.483	1.483
Rv1432_day32	0.889	0.889
Rv1565c_day32	0.599	0.599
secA2_input	-0.977	-0.977
delta_Rv3594	0.754	0.754
delta_Rv3717	-0.876	-0.876
delta_Rv3811	-0.91	-0.91
delta_Rv0954	-3.899	-3.899
PonA1	0.613	0.613
EccD1_KO	0.687	0.687
EspI_KO	1.158	1.158
PE35_KO	-0.522	-0.522
PPE68_KO	0.234	0.234
glycerol2	-2.868	-2.868
lignocerate	-1.335	-1.335
oleate	-2.77	-2.77
phosphatidylcholine	-2.615	-2.615
acetate	-0.716	-0.716
glucAc	-0.692	-0.692
Rv0950ko	-0.501	-0.501
Rv1096ko	1.858	1.858
Rv3684ko	0.534	0.534
delta_otsA_trehalose	1.783	1.783