TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0921/-:

update plot	correlation	link to info on gene
Rv0232/-	(cc=0.6382)	info on Rv0232/-
Rv3329/-	(cc=0.585)	info on Rv3329/-
Rv0083/-	(cc=0.5267)	info on Rv0083/-
Rv0314c/-	(cc=0.5062)	info on Rv0314c/-
Rv3406/-	(cc=0.4886)	info on Rv3406/-
Rv0230c/php	(cc=0.4794)	info on Rv0230c/php
Rv3473c/bpoA	(cc=0.4782)	info on Rv3473c/bpoA
Rv1159A/-	(cc=0.4778)	info on Rv1159A/-
Rv1143/mcr	(cc=0.4757)	info on Rv1143/mcr
Rv0934/pstS1	(cc=0.4733)	info on Rv0934/pstS1

Correlation of Rv0921/- with Rv0232/-

Normalized LFCs for Rv0921/-:
(description and provenance of datasets)

	Rv0921/-	Rv0232/-
Fe_supp_jason_reseq	0.559	-0.499
low_pH_jason_reseq	-0.806	-0.059
NO_jason_reseq	-1.397	-0.171
B6_jason_reseq	0.841	0.053
MHCII_jason_reseq	1.168	0.166
Isoniazid02	-2.772	-1.643
Rifampicin4	0.544	0.368
Ethambutol3	-2.452	-1.762
Meropenem3	-2.192	-1.523
Vancomycin16	-1.072	-1.051
Rv2680_day32	1.328	0.441
H37Rv_KO_MarP	0.423	0.03
hypoxia_3wks	0.506	0.207
hypoxia_6wks	-0.835	0.388
glycerol	-1.145	-0.363
cholesterol	-0.304	0.037
AJ	0.724	-0.067
Bibs02	0.742	0.262
Bibs02c	-0.227	-0.232
BL6	0.278	0.179
BL6a	0.112	-0.303
BXD01	0.354	-0.292
BXD010	0.589	-0.766
BXD011	0.145	-0.178
BXD03	0.6	0.546
BXD04	0.617	1.058
BXD05	0.829	0.183
BXD06	0.456	-0.226
BXD07	0.367	-0.153
BXD08	0.085	0.715
BXD09	0.632	-0.057
CAST	-0.652	0.354
CCcont	0.391	-0.106
DS01	0.178	0.118
DS02	0.189	0.098
DS04	-0.284	-0.828
DS0c	0.371	0.71
GP01	-0.512	-0.049
GP02	1.263	0.568
GP0c	-0.614	0.167
NOD	-0.661	-0.661
NZO	0.423	-0.24
PWK	0.436	0.077
H37Rv_KO_CtpC	-0.325	-0.331
H37Rv_KO_CtpD	-1.413	-0.097
H37Rv_KO_Rv1272	-0.731	-1.309
H37Rv_KO_SugABC	0.293	0.014
H37Rv_KO_MbtN	-1.175	0.205
Trans05	-1.426	-0.686
macrophage_unactivated	1.061	0.271
IL1	0.516	0.427
Rapamycin	0.819	0.479
Tcell	0.704	0.28
GMCSF	0.66	0.544
IFNab	0.472	0.883
IFNg	1.43	0.198
IFNg_GMCSF1	0.525	0.311
Rv1432_day32	0.716	0.445
Rv1565c_day32	0.559	-0.199
secA2_input	0.956	0.988
delta_Rv3594	-0.482	-0.795
delta_Rv3717	-0.831	-0.113
delta_Rv3811	0.28	-0.393
delta_Rv0954	0.6	0.022
PonA1	0.88	-0.305
EccD1_KO	0.132	-0.572
EspI_KO	0.294	-0.302
PE35_KO	0.163	-0.811
PPE68_KO	-0.298	-1.206
glycerol2	-0.081	0.912
lignocerate	0.208	0.81
oleate	0.086	0.682
phosphatidylcholine	0.189	0.945
acetate	0.367	0.055
glucAc	0.069	-0.024
Rv0950ko	0.847	0.697
Rv1096ko	1.252	0.67
Rv3684ko	1.588	0.458
delta_otsA_trehalose	-1.548	-2.297