TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0917/betP:
none

Correlation of Rv0917/betP with Rv0917/betP

Normalized LFCs for Rv0917/betP:
(description and provenance of datasets)

	Rv0917/betP	Rv0917/betP
Fe_supp_jason_reseq	-0.024	-0.024
low_pH_jason_reseq	-0.594	-0.594
NO_jason_reseq	-0.144	-0.144
B6_jason_reseq	0.861	0.861
MHCII_jason_reseq	0.228	0.228
Isoniazid02	-0.115	-0.115
Rifampicin4	0.263	0.263
Ethambutol3	1.154	1.154
Meropenem3	0.704	0.704
Vancomycin16	0.409	0.409
Rv2680_day32	0.077	0.077
H37Rv_KO_MarP	0.267	0.267
hypoxia_3wks	-0.179	-0.179
hypoxia_6wks	0.09	0.09
glycerol	-0.373	-0.373
cholesterol	-0.229	-0.229
AJ	-0.108	-0.108
Bibs02	0.383	0.383
Bibs02c	0.34	0.34
BL6	0.636	0.636
BL6a	0.301	0.301
BXD01	0.63	0.63
BXD010	0.834	0.834
BXD011	0.853	0.853
BXD03	0.545	0.545
BXD04	0.293	0.293
BXD05	0.5	0.5
BXD06	0.84	0.84
BXD07	0.531	0.531
BXD08	0.494	0.494
BXD09	0.442	0.442
CAST	0.282	0.282
CCcont	0.354	0.354
DS01	0.205	0.205
DS02	0.476	0.476
DS04	0.905	0.905
DS0c	0.013	0.013
GP01	0.07	0.07
GP02	0.286	0.286
GP0c	-0.123	-0.123
NOD	0.33	0.33
NZO	-0.423	-0.423
PWK	0.18	0.18
H37Rv_KO_CtpC	0.673	0.673
H37Rv_KO_CtpD	0.217	0.217
H37Rv_KO_Rv1272	0.601	0.601
H37Rv_KO_SugABC	0.663	0.663
H37Rv_KO_MbtN	0.131	0.131
Trans05	0.585	0.585
macrophage_unactivated	-0.022	-0.022
IL1	0.083	0.083
Rapamycin	-0.153	-0.153
Tcell	0.244	0.244
GMCSF	0.354	0.354
IFNab	-0.172	-0.172
IFNg	0.358	0.358
IFNg_GMCSF1	-0.088	-0.088
Rv1432_day32	-0.11	-0.11
Rv1565c_day32	0.208	0.208
secA2_input	-0.321	-0.321
delta_Rv3594	-0.092	-0.092
delta_Rv3717	-0.349	-0.349
delta_Rv3811	-0.116	-0.116
delta_Rv0954	0.106	0.106
PonA1	-0.13	-0.13
EccD1_KO	-0.47	-0.47
EspI_KO	-0.2	-0.2
PE35_KO	0.131	0.131
PPE68_KO	-0.198	-0.198
glycerol2	0.367	0.367
lignocerate	0.319	0.319
oleate	0.432	0.432
phosphatidylcholine	0.497	0.497
acetate	-0.148	-0.148
glucAc	-0.042	-0.042
Rv0950ko	-0.036	-0.036
Rv1096ko	-0.353	-0.353
Rv3684ko	-0.252	-0.252
delta_otsA_trehalose	0.476	0.476