TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0775/-:

update plot	correlation	link to info on gene
Rv0091/mtn	(cc=0.4864)	info on Rv0091/mtn
Rv3463/-	(cc=0.4486)	info on Rv3463/-
Rv3026c/-	(cc=0.4381)	info on Rv3026c/-
Rv0730/-	(cc=0.4245)	info on Rv0730/-
Rv3331/sugI	(cc=0.4231)	info on Rv3331/sugI
Rv1087/PE_PGRS21	(cc=0.4169)	info on Rv1087/PE_PGRS21
Rv3504/fadE26	(cc=0.4149)	info on Rv3504/fadE26
Rv0115/hddA	(cc=0.4142)	info on Rv0115/hddA
Rv3329/-	(cc=0.4109)	info on Rv3329/-
Rv0961/-	(cc=0.4104)	info on Rv0961/-

Correlation of Rv0775/- with Rv0091/mtn

Normalized LFCs for Rv0775/-:
(description and provenance of datasets)

	Rv0775/-	Rv0091/mtn
Fe_supp_jason_reseq	-0.721	-1.195
low_pH_jason_reseq	-0.177	-0.49
NO_jason_reseq	0.242	-0.087
B6_jason_reseq	-0.25	-0.522
MHCII_jason_reseq	-0.624	0.127
Isoniazid02	-1.404	-0.55
Rifampicin4	0.707	-0.127
Ethambutol3	-0.291	0.951
Meropenem3	-0.213	-1.15
Vancomycin16	-0.154	-0.096
Rv2680_day32	1.067	0.556
H37Rv_KO_MarP	0.676	0.398
hypoxia_3wks	0.02	0.471
hypoxia_6wks	0.837	0.856
glycerol	0.688	1.027
cholesterol	0.29	0.27
AJ	0.215	0.474
Bibs02	-0.621	-0.546
Bibs02c	0.0	-0.085
BL6	-0.014	0.796
BL6a	0.075	0.283
BXD01	0.298	0.649
BXD010	0.336	0.137
BXD011	0.394	0.077
BXD03	0.191	-0.095
BXD04	0.232	0.831
BXD05	-0.195	0.294
BXD06	-0.305	0.475
BXD07	0.052	0.134
BXD08	0.392	0.248
BXD09	0.005	0.122
CAST	0.053	-0.41
CCcont	0.095	0.607
DS01	0.443	-0.068
DS02	0.66	-0.05
DS04	1.116	0.396
DS0c	0.53	0.211
GP01	0.247	0.111
GP02	0.552	0.555
GP0c	-0.581	-0.657
NOD	-0.74	-1.199
NZO	1.084	0.694
PWK	0.449	-0.443
H37Rv_KO_CtpC	0.726	-0.867
H37Rv_KO_CtpD	0.221	0.778
H37Rv_KO_Rv1272	-0.581	0.173
H37Rv_KO_SugABC	1.375	0.146
H37Rv_KO_MbtN	-0.708	-0.958
Trans05	-1.485	-0.536
macrophage_unactivated	-1.247	-0.593
IL1	-0.424	-0.056
Rapamycin	-0.586	0.476
Tcell	-0.528	0.652
GMCSF	-0.367	-1.69
IFNab	-0.789	-0.254
IFNg	-0.671	0.15
IFNg_GMCSF1	-0.588	0.195
Rv1432_day32	-0.124	0.506
Rv1565c_day32	0.019	-1.017
secA2_input	-0.142	0.589
delta_Rv3594	-0.841	-0.584
delta_Rv3717	-0.189	-0.466
delta_Rv3811	-0.979	-0.677
delta_Rv0954	-0.047	0.092
PonA1	0.375	0.216
EccD1_KO	-0.092	-0.247
EspI_KO	0.302	0.16
PE35_KO	-0.438	-0.344
PPE68_KO	-1.171	-0.24
glycerol2	0.378	1.588
lignocerate	0.477	1.37
oleate	0.763	1.085
phosphatidylcholine	0.629	1.196
acetate	-0.09	0.73
glucAc	-0.301	0.4
Rv0950ko	0.498	0.084
Rv1096ko	0.742	0.112
Rv3684ko	0.701	0.092
delta_otsA_trehalose	0.776	1.141