TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0763c/-:
none

Correlation of Rv0763c/- with Rv0763c/-

Normalized LFCs for Rv0763c/-:
(description and provenance of datasets)

	Rv0763c/-	Rv0763c/-
Fe_supp_jason_reseq	0.598	0.598
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	1.811	1.811
MHCII_jason_reseq	2.803	2.803
Isoniazid02	0.0	0.0
Rifampicin4	0.0	0.0
Ethambutol3	0.0	0.0
Meropenem3	0.165	0.165
Vancomycin16	0.366	0.366
Rv2680_day32	-1.078	-1.078
H37Rv_KO_MarP	0.329	0.329
hypoxia_3wks	-0.459	-0.459
hypoxia_6wks	-0.791	-0.791
glycerol	1.695	1.695
cholesterol	-1.663	-1.663
AJ	-1.239	-1.239
Bibs02	-1.325	-1.325
Bibs02c	-2.402	-2.402
BL6	-1.436	-1.436
BL6a	-2.274	-2.274
BXD01	-1.496	-1.496
BXD010	-1.471	-1.471
BXD011	0.416	0.416
BXD03	-1.553	-1.553
BXD04	-1.42	-1.42
BXD05	-1.545	-1.545
BXD06	-1.533	-1.533
BXD07	-1.59	-1.59
BXD08	-1.527	-1.527
BXD09	-1.614	-1.614
CAST	-0.976	-0.976
CCcont	-1.715	-1.715
DS01	-1.128	-1.128
DS02	-2.497	-2.497
DS04	0.312	0.312
DS0c	-2.49	-2.49
GP01	0.371	0.371
GP02	-0.663	-0.663
GP0c	-0.771	-0.771
NOD	-2.579	-2.579
NZO	2.146	2.146
PWK	0.132	0.132
H37Rv_KO_CtpC	-1.865	-1.865
H37Rv_KO_CtpD	-1.107	-1.107
H37Rv_KO_Rv1272	-0.391	-0.391
H37Rv_KO_SugABC	-1.038	-1.038
H37Rv_KO_MbtN	-0.611	-0.611
Trans05	4.977	4.977
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.18	0.18
Rv1565c_day32	0.0	0.0
secA2_input	3.187	3.187
delta_Rv3594	1.579	1.579
delta_Rv3717	0.331	0.331
delta_Rv3811	1.068	1.068
delta_Rv0954	1.163	1.163
PonA1	-2.505	-2.505
EccD1_KO	0.27	0.27
EspI_KO	4.095	4.095
PE35_KO	2.917	2.917
PPE68_KO	3.2	3.2
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	1.221	1.221
Rv1096ko	2.775	2.775
Rv3684ko	0.819	0.819
delta_otsA_trehalose	0.849	0.849