TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0749A/-:
none

Correlation of Rv0749A/- with Rv0749A/-

Normalized LFCs for Rv0749A/-:
(description and provenance of datasets)

	Rv0749A/-	Rv0749A/-
Fe_supp_jason_reseq	1.964	1.964
low_pH_jason_reseq	-5.222	-5.222
NO_jason_reseq	1.961	1.961
B6_jason_reseq	0.502	0.502
MHCII_jason_reseq	-3.05	-3.05
Isoniazid02	-0.757	-0.757
Rifampicin4	-0.376	-0.376
Ethambutol3	-0.478	-0.478
Meropenem3	-0.41	-0.41
Vancomycin16	-0.608	-0.608
Rv2680_day32	-1.153	-1.153
H37Rv_KO_MarP	0.961	0.961
hypoxia_3wks	-0.415	-0.415
hypoxia_6wks	1.102	1.102
glycerol	-0.521	-0.521
cholesterol	0.4	0.4
AJ	0.439	0.439
Bibs02	-1.722	-1.722
Bibs02c	1.852	1.852
BL6	1.042	1.042
BL6a	0.868	0.868
BXD01	-1.335	-1.335
BXD010	1.419	1.419
BXD011	-1.845	-1.845
BXD03	-2.939	-2.939
BXD04	-1.503	-1.503
BXD05	-1.231	-1.231
BXD06	-2.5	-2.5
BXD07	1.047	1.047
BXD08	-1.927	-1.927
BXD09	-1.146	-1.146
CAST	0.821	0.821
CCcont	-1.531	-1.531
DS01	0.613	0.613
DS02	-4.726	-4.726
DS04	-4.586	-4.586
DS0c	-1.769	-1.769
GP01	-2.334	-2.334
GP02	-1.967	-1.967
GP0c	-3.073	-3.073
NOD	3.58	3.58
NZO	-0.6	-0.6
PWK	1.312	1.312
H37Rv_KO_CtpC	-3.84	-3.84
H37Rv_KO_CtpD	1.531	1.531
H37Rv_KO_Rv1272	-2.641	-2.641
H37Rv_KO_SugABC	-2.153	-2.153
H37Rv_KO_MbtN	-2.074	-2.074
Trans05	-0.058	-0.058
macrophage_unactivated	-5.808	-5.808
IL1	-2.165	-2.165
Rapamycin	-2.029	-2.029
Tcell	-2.046	-2.046
GMCSF	0.805	0.805
IFNab	-1.342	-1.342
IFNg	-2.56	-2.56
IFNg_GMCSF1	0.383	0.383
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-2.079	-2.079
delta_Rv3594	1.67	1.67
delta_Rv3717	2.55	2.55
delta_Rv3811	0.849	0.849
delta_Rv0954	1.56	1.56
PonA1	-3.193	-3.193
EccD1_KO	2.026	2.026
EspI_KO	2.341	2.341
PE35_KO	3.666	3.666
PPE68_KO	-0.122	-0.122
glycerol2	0.0	0.0
lignocerate	0.32	0.32
oleate	0.961	0.961
phosphatidylcholine	0.193	0.193
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	-1.764	-1.764
Rv1096ko	-3.073	-3.073
Rv3684ko	-0.216	-0.216
delta_otsA_trehalose	1.261	1.261