TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0748/vapB31:
none

Correlation of Rv0748/vapB31 with Rv0748/vapB31

Normalized LFCs for Rv0748/vapB31:
(description and provenance of datasets)

	Rv0748/vapB31	Rv0748/vapB31
Fe_supp_jason_reseq	-0.347	-0.347
low_pH_jason_reseq	-1.419	-1.419
NO_jason_reseq	-1.26	-1.26
B6_jason_reseq	0.748	0.748
MHCII_jason_reseq	2.936	2.936
Isoniazid02	0.901	0.901
Rifampicin4	0.284	0.284
Ethambutol3	1.813	1.813
Meropenem3	0.126	0.126
Vancomycin16	0.541	0.541
Rv2680_day32	0.846	0.846
H37Rv_KO_MarP	-1.411	-1.411
hypoxia_3wks	-1.132	-1.132
hypoxia_6wks	-0.196	-0.196
glycerol	0.674	0.674
cholesterol	0.025	0.025
AJ	2.0	2.0
Bibs02	0.184	0.184
Bibs02c	-0.22	-0.22
BL6	0.783	0.783
BL6a	-0.868	-0.868
BXD01	-1.27	-1.27
BXD010	-3.311	-3.311
BXD011	-2.128	-2.128
BXD03	-2.613	-2.613
BXD04	-1.897	-1.897
BXD05	-0.651	-0.651
BXD06	-2.58	-2.58
BXD07	-1.927	-1.927
BXD08	-0.064	-0.064
BXD09	-0.604	-0.604
CAST	1.351	1.351
CCcont	0.221	0.221
DS01	0.096	0.096
DS02	-0.271	-0.271
DS04	0.122	0.122
DS0c	0.025	0.025
GP01	-2.309	-2.309
GP02	-2.151	-2.151
GP0c	-3.665	-3.665
NOD	1.064	1.064
NZO	1.929	1.929
PWK	-0.155	-0.155
H37Rv_KO_CtpC	-0.482	-0.482
H37Rv_KO_CtpD	-0.662	-0.662
H37Rv_KO_Rv1272	-2.835	-2.835
H37Rv_KO_SugABC	0.588	0.588
H37Rv_KO_MbtN	-0.17	-0.17
Trans05	-0.224	-0.224
macrophage_unactivated	-1.13	-1.13
IL1	0.0	0.0
Rapamycin	-2.808	-2.808
Tcell	-0.371	-0.371
GMCSF	-1.677	-1.677
IFNab	-0.916	-0.916
IFNg	-0.273	-0.273
IFNg_GMCSF1	0.17	0.17
Rv1432_day32	0.42	0.42
Rv1565c_day32	1.61	1.61
secA2_input	-0.767	-0.767
delta_Rv3594	0.687	0.687
delta_Rv3717	-0.073	-0.073
delta_Rv3811	-0.216	-0.216
delta_Rv0954	-1.996	-1.996
PonA1	-1.955	-1.955
EccD1_KO	-0.395	-0.395
EspI_KO	-0.04	-0.04
PE35_KO	-0.805	-0.805
PPE68_KO	-0.022	-0.022
glycerol2	-0.296	-0.296
lignocerate	0.071	0.071
oleate	0.369	0.369
phosphatidylcholine	0.213	0.213
acetate	-0.143	-0.143
glucAc	-0.614	-0.614
Rv0950ko	0.992	0.992
Rv1096ko	1.327	1.327
Rv3684ko	0.354	0.354
delta_otsA_trehalose	1.293	1.293