TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0729/xylB:
none

Correlation of Rv0729/xylB with Rv0729/xylB

Normalized LFCs for Rv0729/xylB:
(description and provenance of datasets)

	Rv0729/xylB	Rv0729/xylB
Fe_supp_jason_reseq	-0.455	-0.455
low_pH_jason_reseq	-0.453	-0.453
NO_jason_reseq	-0.832	-0.832
B6_jason_reseq	-0.333	-0.333
MHCII_jason_reseq	0.429	0.429
Isoniazid02	-0.009	-0.009
Rifampicin4	0.141	0.141
Ethambutol3	-0.051	-0.051
Meropenem3	0.563	0.563
Vancomycin16	0.061	0.061
Rv2680_day32	0.472	0.472
H37Rv_KO_MarP	0.159	0.159
hypoxia_3wks	-0.052	-0.052
hypoxia_6wks	-0.14	-0.14
glycerol	0.616	0.616
cholesterol	0.125	0.125
AJ	0.151	0.151
Bibs02	-0.27	-0.27
Bibs02c	-0.346	-0.346
BL6	-0.401	-0.401
BL6a	-0.389	-0.389
BXD01	-0.64	-0.64
BXD010	-0.385	-0.385
BXD011	-0.068	-0.068
BXD03	-0.105	-0.105
BXD04	-0.74	-0.74
BXD05	0.125	0.125
BXD06	-0.624	-0.624
BXD07	-0.336	-0.336
BXD08	-0.232	-0.232
BXD09	-0.053	-0.053
CAST	0.033	0.033
CCcont	-0.605	-0.605
DS01	0.228	0.228
DS02	0.481	0.481
DS04	0.672	0.672
DS0c	0.126	0.126
GP01	-0.061	-0.061
GP02	0.204	0.204
GP0c	0.371	0.371
NOD	-0.295	-0.295
NZO	0.316	0.316
PWK	0.222	0.222
H37Rv_KO_CtpC	0.145	0.145
H37Rv_KO_CtpD	0.018	0.018
H37Rv_KO_Rv1272	-0.701	-0.701
H37Rv_KO_SugABC	-0.217	-0.217
H37Rv_KO_MbtN	0.049	0.049
Trans05	-0.558	-0.558
macrophage_unactivated	-0.641	-0.641
IL1	0.225	0.225
Rapamycin	0.328	0.328
Tcell	-0.437	-0.437
GMCSF	0.158	0.158
IFNab	0.133	0.133
IFNg	0.118	0.118
IFNg_GMCSF1	0.622	0.622
Rv1432_day32	-0.121	-0.121
Rv1565c_day32	-0.141	-0.141
secA2_input	0.878	0.878
delta_Rv3594	0.297	0.297
delta_Rv3717	0.586	0.586
delta_Rv3811	0.012	0.012
delta_Rv0954	0.696	0.696
PonA1	0.428	0.428
EccD1_KO	0.898	0.898
EspI_KO	0.616	0.616
PE35_KO	-0.163	-0.163
PPE68_KO	0.0	0.0
glycerol2	0.376	0.376
lignocerate	0.716	0.716
oleate	0.139	0.139
phosphatidylcholine	0.364	0.364
acetate	0.219	0.219
glucAc	0.127	0.127
Rv0950ko	0.461	0.461
Rv1096ko	0.214	0.214
Rv3684ko	-0.196	-0.196
delta_otsA_trehalose	-0.73	-0.73