TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0711/atsA:
none

Correlation of Rv0711/atsA with Rv0711/atsA

Normalized LFCs for Rv0711/atsA:
(description and provenance of datasets)

	Rv0711/atsA	Rv0711/atsA
Fe_supp_jason_reseq	-0.013	-0.013
low_pH_jason_reseq	-0.979	-0.979
NO_jason_reseq	-0.318	-0.318
B6_jason_reseq	0.115	0.115
MHCII_jason_reseq	0.131	0.131
Isoniazid02	-0.826	-0.826
Rifampicin4	-0.666	-0.666
Ethambutol3	-0.42	-0.42
Meropenem3	0.074	0.074
Vancomycin16	-0.562	-0.562
Rv2680_day32	0.639	0.639
H37Rv_KO_MarP	0.344	0.344
hypoxia_3wks	-0.251	-0.251
hypoxia_6wks	-0.549	-0.549
glycerol	-0.565	-0.565
cholesterol	-0.372	-0.372
AJ	0.398	0.398
Bibs02	0.212	0.212
Bibs02c	0.558	0.558
BL6	0.779	0.779
BL6a	0.773	0.773
BXD01	0.172	0.172
BXD010	0.387	0.387
BXD011	0.537	0.537
BXD03	0.586	0.586
BXD04	0.814	0.814
BXD05	0.768	0.768
BXD06	0.374	0.374
BXD07	0.331	0.331
BXD08	-0.08	-0.08
BXD09	0.349	0.349
CAST	0.497	0.497
CCcont	0.378	0.378
DS01	0.161	0.161
DS02	0.076	0.076
DS04	0.163	0.163
DS0c	0.33	0.33
GP01	0.324	0.324
GP02	0.357	0.357
GP0c	0.299	0.299
NOD	0.698	0.698
NZO	0.73	0.73
PWK	0.111	0.111
H37Rv_KO_CtpC	0.395	0.395
H37Rv_KO_CtpD	0.448	0.448
H37Rv_KO_Rv1272	0.073	0.073
H37Rv_KO_SugABC	0.444	0.444
H37Rv_KO_MbtN	0.414	0.414
Trans05	-0.015	-0.015
macrophage_unactivated	0.0	0.0
IL1	0.489	0.489
Rapamycin	0.089	0.089
Tcell	-0.173	-0.173
GMCSF	-0.238	-0.238
IFNab	0.484	0.484
IFNg	0.577	0.577
IFNg_GMCSF1	0.019	0.019
Rv1432_day32	-0.11	-0.11
Rv1565c_day32	-0.521	-0.521
secA2_input	0.197	0.197
delta_Rv3594	0.171	0.171
delta_Rv3717	-0.088	-0.088
delta_Rv3811	-0.397	-0.397
delta_Rv0954	0.598	0.598
PonA1	0.192	0.192
EccD1_KO	0.026	0.026
EspI_KO	-0.163	-0.163
PE35_KO	-0.68	-0.68
PPE68_KO	-0.346	-0.346
glycerol2	0.304	0.304
lignocerate	0.695	0.695
oleate	-0.044	-0.044
phosphatidylcholine	0.228	0.228
acetate	0.487	0.487
glucAc	0.45	0.45
Rv0950ko	-0.075	-0.075
Rv1096ko	0.627	0.627
Rv3684ko	0.609	0.609
delta_otsA_trehalose	-0.32	-0.32