TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0657c/vapB6:
none

Correlation of Rv0657c/vapB6 with Rv0657c/vapB6

Normalized LFCs for Rv0657c/vapB6:
(description and provenance of datasets)

	Rv0657c/vapB6	Rv0657c/vapB6
Fe_supp_jason_reseq	-0.339	-0.339
low_pH_jason_reseq	-1.372	-1.372
NO_jason_reseq	-2.234	-2.234
B6_jason_reseq	-1.21	-1.21
MHCII_jason_reseq	3.077	3.077
Isoniazid02	-0.108	-0.108
Rifampicin4	-0.69	-0.69
Ethambutol3	-0.389	-0.389
Meropenem3	-0.831	-0.831
Vancomycin16	0.247	0.247
Rv2680_day32	-2.61	-2.61
H37Rv_KO_MarP	0.473	0.473
hypoxia_3wks	0.0	0.0
hypoxia_6wks	-1.681	-1.681
glycerol	-0.468	-0.468
cholesterol	-0.066	-0.066
AJ	-2.148	-2.148
Bibs02	-1.607	-1.607
Bibs02c	-1.026	-1.026
BL6	-3.748	-3.748
BL6a	-0.435	-0.435
BXD01	-2.611	-2.611
BXD010	-2.656	-2.656
BXD011	-1.291	-1.291
BXD03	-0.61	-0.61
BXD04	-3.417	-3.417
BXD05	0.641	0.641
BXD06	-0.884	-0.884
BXD07	-1.536	-1.536
BXD08	-0.367	-0.367
BXD09	0.177	0.177
CAST	-0.681	-0.681
CCcont	-2.042	-2.042
DS01	-1.771	-1.771
DS02	-2.896	-2.896
DS04	-3.824	-3.824
DS0c	-0.979	-0.979
GP01	2.566	2.566
GP02	3.45	3.45
GP0c	1.241	1.241
NOD	0.978	0.978
NZO	-0.855	-0.855
PWK	2.131	2.131
H37Rv_KO_CtpC	-0.81	-0.81
H37Rv_KO_CtpD	1.429	1.429
H37Rv_KO_Rv1272	0.474	0.474
H37Rv_KO_SugABC	-2.439	-2.439
H37Rv_KO_MbtN	0.183	0.183
Trans05	2.266	2.266
macrophage_unactivated	-0.533	-0.533
IL1	1.311	1.311
Rapamycin	-0.199	-0.199
Tcell	-1.652	-1.652
GMCSF	0.607	0.607
IFNab	0.677	0.677
IFNg	-0.51	-0.51
IFNg_GMCSF1	2.319	2.319
Rv1432_day32	-0.18	-0.18
Rv1565c_day32	-1.268	-1.268
secA2_input	0.413	0.413
delta_Rv3594	-1.787	-1.787
delta_Rv3717	-0.286	-0.286
delta_Rv3811	-5.496	-5.496
delta_Rv0954	-4.509	-4.509
PonA1	-0.545	-0.545
EccD1_KO	-0.414	-0.414
EspI_KO	-0.867	-0.867
PE35_KO	-0.578	-0.578
PPE68_KO	-1.267	-1.267
glycerol2	0.0	0.0
lignocerate	1.303	1.303
oleate	0.196	0.196
phosphatidylcholine	0.531	0.531
acetate	3.498	3.498
glucAc	0.0	0.0
Rv0950ko	3.824	3.824
Rv1096ko	3.17	3.17
Rv3684ko	2.518	2.518
delta_otsA_trehalose	-0.503	-0.503