TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0608/vapB28:
none

Correlation of Rv0608/vapB28 with Rv0608/vapB28

Normalized LFCs for Rv0608/vapB28:
(description and provenance of datasets)

	Rv0608/vapB28	Rv0608/vapB28
Fe_supp_jason_reseq	-1.091	-1.091
low_pH_jason_reseq	-1.377	-1.377
NO_jason_reseq	-0.255	-0.255
B6_jason_reseq	-1.255	-1.255
MHCII_jason_reseq	-2.654	-2.654
Isoniazid02	-0.099	-0.099
Rifampicin4	-0.068	-0.068
Ethambutol3	-0.652	-0.652
Meropenem3	-0.438	-0.438
Vancomycin16	0.109	0.109
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	-0.288	-0.288
hypoxia_3wks	-1.344	-1.344
hypoxia_6wks	1.136	1.136
glycerol	1.27	1.27
cholesterol	1.152	1.152
AJ	1.387	1.387
Bibs02	-1.291	-1.291
Bibs02c	-1.634	-1.634
BL6	-2.275	-2.275
BL6a	-3.405	-3.405
BXD01	-2.369	-2.369
BXD010	-1.701	-1.701
BXD011	-1.61	-1.61
BXD03	-2.46	-2.46
BXD04	-2.014	-2.014
BXD05	-1.975	-1.975
BXD06	-1.207	-1.207
BXD07	-2.519	-2.519
BXD08	-1.456	-1.456
BXD09	-2.556	-2.556
CAST	0.724	0.724
CCcont	-2.192	-2.192
DS01	0.898	0.898
DS02	0.154	0.154
DS04	-3.335	-3.335
DS0c	-0.082	-0.082
GP01	-0.291	-0.291
GP02	2.591	2.591
GP0c	1.089	1.089
NOD	0.706	0.706
NZO	-1.139	-1.139
PWK	1.886	1.886
H37Rv_KO_CtpC	-2.955	-2.955
H37Rv_KO_CtpD	-2.304	-2.304
H37Rv_KO_Rv1272	-0.193	-0.193
H37Rv_KO_SugABC	-1.613	-1.613
H37Rv_KO_MbtN	-1.875	-1.875
Trans05	1.548	1.548
macrophage_unactivated	-5.271	-5.271
IL1	-3.349	-3.349
Rapamycin	-1.317	-1.317
Tcell	-5.031	-5.031
GMCSF	-4.771	-4.771
IFNab	-2.44	-2.44
IFNg	-4.463	-4.463
IFNg_GMCSF1	-0.267	-0.267
Rv1432_day32	0.0	0.0
Rv1565c_day32	2.541	2.541
secA2_input	-1.298	-1.298
delta_Rv3594	-0.519	-0.519
delta_Rv3717	-0.029	-0.029
delta_Rv3811	-1.419	-1.419
delta_Rv0954	0.892	0.892
PonA1	-0.14	-0.14
EccD1_KO	0.595	0.595
EspI_KO	2.943	2.943
PE35_KO	1.738	1.738
PPE68_KO	-0.544	-0.544
glycerol2	0.0	0.0
lignocerate	0.32	0.32
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	1.242	1.242
Rv0950ko	-2.542	-2.542
Rv1096ko	-1.188	-1.188
Rv3684ko	-0.871	-0.871
delta_otsA_trehalose	2.593	2.593