TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0607/-:
none

Correlation of Rv0607/- with Rv0607/-

Normalized LFCs for Rv0607/-:
(description and provenance of datasets)

	Rv0607/-	Rv0607/-
Fe_supp_jason_reseq	-0.818	-0.818
low_pH_jason_reseq	-4.442	-4.442
NO_jason_reseq	-0.583	-0.583
B6_jason_reseq	-2.946	-2.946
MHCII_jason_reseq	-2.595	-2.595
Isoniazid02	-0.582	-0.582
Rifampicin4	0.839	0.839
Ethambutol3	0.054	0.054
Meropenem3	-0.698	-0.698
Vancomycin16	0.43	0.43
Rv2680_day32	-0.725	-0.725
H37Rv_KO_MarP	1.446	1.446
hypoxia_3wks	2.508	2.508
hypoxia_6wks	2.767	2.767
glycerol	0.787	0.787
cholesterol	1.189	1.189
AJ	4.459	4.459
Bibs02	-1.387	-1.387
Bibs02c	1.088	1.088
BL6	-1.479	-1.479
BL6a	1.774	1.774
BXD01	0.0	0.0
BXD010	0.162	0.162
BXD011	4.018	4.018
BXD03	1.992	1.992
BXD04	1.378	1.378
BXD05	1.675	1.675
BXD06	0.922	0.922
BXD07	1.51	1.51
BXD08	0.487	0.487
BXD09	3.077	3.077
CAST	-1.054	-1.054
CCcont	-1.765	-1.765
DS01	1.228	1.228
DS02	3.568	3.568
DS04	-1.924	-1.924
DS0c	-1.232	-1.232
GP01	-0.222	-0.222
GP02	0.2	0.2
GP0c	0.623	0.623
NOD	0.656	0.656
NZO	0.867	0.867
PWK	0.362	0.362
H37Rv_KO_CtpC	5.177	5.177
H37Rv_KO_CtpD	-1.151	-1.151
H37Rv_KO_Rv1272	0.871	0.871
H37Rv_KO_SugABC	-1.171	-1.171
H37Rv_KO_MbtN	0.693	0.693
Trans05	3.401	3.401
macrophage_unactivated	-0.65	-0.65
IL1	1.584	1.584
Rapamycin	0.58	0.58
Tcell	0.13	0.13
GMCSF	2.477	2.477
IFNab	1.24	1.24
IFNg	1.331	1.331
IFNg_GMCSF1	0.811	0.811
Rv1432_day32	-0.494	-0.494
Rv1565c_day32	0.0	0.0
secA2_input	-2.376	-2.376
delta_Rv3594	4.356	4.356
delta_Rv3717	0.0	0.0
delta_Rv3811	3.495	3.495
delta_Rv0954	2.439	2.439
PonA1	3.483	3.483
EccD1_KO	0.47	0.47
EspI_KO	1.315	1.315
PE35_KO	2.806	2.806
PPE68_KO	2.627	2.627
glycerol2	-2.33	-2.33
lignocerate	-1.128	-1.128
oleate	-1.313	-1.313
phosphatidylcholine	-1.748	-1.748
acetate	-3.202	-3.202
glucAc	-1.991	-1.991
Rv0950ko	1.785	1.785
Rv1096ko	0.492	0.492
Rv3684ko	-6.0	-6.0
delta_otsA_trehalose	1.159	1.159