TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0594/mce2F:
none

Correlation of Rv0594/mce2F with Rv0594/mce2F

Normalized LFCs for Rv0594/mce2F:
(description and provenance of datasets)

	Rv0594/mce2F	Rv0594/mce2F
Fe_supp_jason_reseq	-0.317	-0.317
low_pH_jason_reseq	-0.755	-0.755
NO_jason_reseq	0.517	0.517
B6_jason_reseq	0.161	0.161
MHCII_jason_reseq	0.222	0.222
Isoniazid02	-0.191	-0.191
Rifampicin4	-0.035	-0.035
Ethambutol3	0.101	0.101
Meropenem3	-0.08	-0.08
Vancomycin16	0.236	0.236
Rv2680_day32	-0.121	-0.121
H37Rv_KO_MarP	0.604	0.604
hypoxia_3wks	0.044	0.044
hypoxia_6wks	0.334	0.334
glycerol	-0.095	-0.095
cholesterol	0.913	0.913
AJ	0.252	0.252
Bibs02	0.135	0.135
Bibs02c	0.382	0.382
BL6	0.303	0.303
BL6a	0.075	0.075
BXD01	0.238	0.238
BXD010	0.648	0.648
BXD011	0.636	0.636
BXD03	-0.217	-0.217
BXD04	0.156	0.156
BXD05	-0.112	-0.112
BXD06	0.118	0.118
BXD07	0.146	0.146
BXD08	0.217	0.217
BXD09	0.026	0.026
CAST	0.052	0.052
CCcont	0.034	0.034
DS01	0.46	0.46
DS02	0.296	0.296
DS04	0.322	0.322
DS0c	0.737	0.737
GP01	-0.347	-0.347
GP02	0.485	0.485
GP0c	-0.056	-0.056
NOD	-0.151	-0.151
NZO	0.155	0.155
PWK	0.186	0.186
H37Rv_KO_CtpC	0.312	0.312
H37Rv_KO_CtpD	0.314	0.314
H37Rv_KO_Rv1272	0.125	0.125
H37Rv_KO_SugABC	0.334	0.334
H37Rv_KO_MbtN	0.433	0.433
Trans05	-0.364	-0.364
macrophage_unactivated	-0.622	-0.622
IL1	-0.193	-0.193
Rapamycin	-0.292	-0.292
Tcell	-0.039	-0.039
GMCSF	-0.52	-0.52
IFNab	-0.674	-0.674
IFNg	-0.337	-0.337
IFNg_GMCSF1	-0.167	-0.167
Rv1432_day32	0.269	0.269
Rv1565c_day32	0.269	0.269
secA2_input	0.089	0.089
delta_Rv3594	-0.072	-0.072
delta_Rv3717	-0.05	-0.05
delta_Rv3811	-0.051	-0.051
delta_Rv0954	0.344	0.344
PonA1	0.609	0.609
EccD1_KO	0.141	0.141
EspI_KO	0.194	0.194
PE35_KO	-0.365	-0.365
PPE68_KO	-0.205	-0.205
glycerol2	0.371	0.371
lignocerate	0.443	0.443
oleate	0.082	0.082
phosphatidylcholine	0.415	0.415
acetate	0.121	0.121
glucAc	0.259	0.259
Rv0950ko	0.039	0.039
Rv1096ko	0.139	0.139
Rv3684ko	0.151	0.151
delta_otsA_trehalose	-0.664	-0.664