TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0426c/-:
none

Correlation of Rv0426c/- with Rv0426c/-

Normalized LFCs for Rv0426c/-:
(description and provenance of datasets)

	Rv0426c/-	Rv0426c/-
Fe_supp_jason_reseq	-0.9	-0.9
low_pH_jason_reseq	-1.223	-1.223
NO_jason_reseq	0.378	0.378
B6_jason_reseq	-2.161	-2.161
MHCII_jason_reseq	-1.425	-1.425
Isoniazid02	-0.282	-0.282
Rifampicin4	0.552	0.552
Ethambutol3	0.238	0.238
Meropenem3	0.788	0.788
Vancomycin16	-0.138	-0.138
Rv2680_day32	3.42	3.42
H37Rv_KO_MarP	0.334	0.334
hypoxia_3wks	1.778	1.778
hypoxia_6wks	1.744	1.744
glycerol	-0.856	-0.856
cholesterol	0.646	0.646
AJ	-2.187	-2.187
Bibs02	-0.96	-0.96
Bibs02c	-0.427	-0.427
BL6	1.293	1.293
BL6a	0.689	0.689
BXD01	1.057	1.057
BXD010	1.046	1.046
BXD011	1.518	1.518
BXD03	2.194	2.194
BXD04	0.959	0.959
BXD05	0.694	0.694
BXD06	0.801	0.801
BXD07	1.349	1.349
BXD08	1.413	1.413
BXD09	1.688	1.688
CAST	0.487	0.487
CCcont	-0.449	-0.449
DS01	-0.845	-0.845
DS02	-2.24	-2.24
DS04	-2.412	-2.412
DS0c	0.858	0.858
GP01	-1.476	-1.476
GP02	1.06	1.06
GP0c	-1.884	-1.884
NOD	-1.479	-1.479
NZO	-3.875	-3.875
PWK	-0.203	-0.203
H37Rv_KO_CtpC	-2.429	-2.429
H37Rv_KO_CtpD	-2.461	-2.461
H37Rv_KO_Rv1272	0.412	0.412
H37Rv_KO_SugABC	1.089	1.089
H37Rv_KO_MbtN	-0.09	-0.09
Trans05	-1.007	-1.007
macrophage_unactivated	-1.685	-1.685
IL1	-0.564	-0.564
Rapamycin	-0.921	-0.921
Tcell	0.534	0.534
GMCSF	-0.927	-0.927
IFNab	-1.079	-1.079
IFNg	-0.545	-0.545
IFNg_GMCSF1	-0.566	-0.566
Rv1432_day32	0.819	0.819
Rv1565c_day32	0.365	0.365
secA2_input	-3.024	-3.024
delta_Rv3594	0.33	0.33
delta_Rv3717	3.102	3.102
delta_Rv3811	2.089	2.089
delta_Rv0954	0.792	0.792
PonA1	-1.522	-1.522
EccD1_KO	-2.102	-2.102
EspI_KO	-0.476	-0.476
PE35_KO	-2.004	-2.004
PPE68_KO	-2.665	-2.665
glycerol2	-0.339	-0.339
lignocerate	-0.105	-0.105
oleate	0.345	0.345
phosphatidylcholine	-0.02	-0.02
acetate	0.434	0.434
glucAc	0.257	0.257
Rv0950ko	-1.553	-1.553
Rv1096ko	-2.15	-2.15
Rv3684ko	-0.095	-0.095
delta_otsA_trehalose	-1.628	-1.628