TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0405/pks6:
none

Correlation of Rv0405/pks6 with Rv0405/pks6

Normalized LFCs for Rv0405/pks6:
(description and provenance of datasets)

	Rv0405/pks6	Rv0405/pks6
Fe_supp_jason_reseq	-0.167	-0.167
low_pH_jason_reseq	-0.611	-0.611
NO_jason_reseq	-0.045	-0.045
B6_jason_reseq	-0.289	-0.289
MHCII_jason_reseq	0.017	0.017
Isoniazid02	0.109	0.109
Rifampicin4	-0.341	-0.341
Ethambutol3	-0.054	-0.054
Meropenem3	-0.624	-0.624
Vancomycin16	-0.698	-0.698
Rv2680_day32	0.459	0.459
H37Rv_KO_MarP	0.317	0.317
hypoxia_3wks	0.355	0.355
hypoxia_6wks	0.0	0.0
glycerol	-0.053	-0.053
cholesterol	0.159	0.159
AJ	0.534	0.534
Bibs02	0.024	0.024
Bibs02c	0.547	0.547
BL6	0.016	0.016
BL6a	0.456	0.456
BXD01	-0.278	-0.278
BXD010	0.141	0.141
BXD011	0.14	0.14
BXD03	0.165	0.165
BXD04	0.047	0.047
BXD05	0.338	0.338
BXD06	0.017	0.017
BXD07	-0.073	-0.073
BXD08	0.099	0.099
BXD09	0.138	0.138
CAST	0.864	0.864
CCcont	-0.575	-0.575
DS01	0.12	0.12
DS02	0.055	0.055
DS04	0.526	0.526
DS0c	0.264	0.264
GP01	-0.052	-0.052
GP02	0.438	0.438
GP0c	-0.034	-0.034
NOD	1.036	1.036
NZO	0.051	0.051
PWK	0.348	0.348
H37Rv_KO_CtpC	0.565	0.565
H37Rv_KO_CtpD	0.381	0.381
H37Rv_KO_Rv1272	0.235	0.235
H37Rv_KO_SugABC	0.344	0.344
H37Rv_KO_MbtN	-0.158	-0.158
Trans05	0.26	0.26
macrophage_unactivated	0.83	0.83
IL1	-0.219	-0.219
Rapamycin	-0.227	-0.227
Tcell	0.0	0.0
GMCSF	0.275	0.275
IFNab	-0.166	-0.166
IFNg	0.233	0.233
IFNg_GMCSF1	0.38	0.38
Rv1432_day32	0.219	0.219
Rv1565c_day32	-0.283	-0.283
secA2_input	-0.481	-0.481
delta_Rv3594	0.058	0.058
delta_Rv3717	-0.435	-0.435
delta_Rv3811	-0.117	-0.117
delta_Rv0954	-0.05	-0.05
PonA1	0.188	0.188
EccD1_KO	-0.395	-0.395
EspI_KO	-0.342	-0.342
PE35_KO	-0.537	-0.537
PPE68_KO	-0.384	-0.384
glycerol2	0.045	0.045
lignocerate	-0.32	-0.32
oleate	0.373	0.373
phosphatidylcholine	0.172	0.172
acetate	-0.253	-0.253
glucAc	-0.907	-0.907
Rv0950ko	0.277	0.277
Rv1096ko	-0.247	-0.247
Rv3684ko	-0.105	-0.105
delta_otsA_trehalose	0.286	0.286