TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0384c/clpB:
none

Correlation of Rv0384c/clpB with Rv0384c/clpB

Normalized LFCs for Rv0384c/clpB:
(description and provenance of datasets)

	Rv0384c/clpB	Rv0384c/clpB
Fe_supp_jason_reseq	0.0	0.0
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	-0.383	-0.383
Rifampicin4	-0.712	-0.712
Ethambutol3	-0.32	-0.32
Meropenem3	-0.315	-0.315
Vancomycin16	-0.698	-0.698
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	-0.226	-0.226
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	0.0	0.0
cholesterol	0.0	0.0
AJ	0.0	0.0
Bibs02	0.0	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	0.0	0.0
BXD01	0.0	0.0
BXD010	0.0	0.0
BXD011	0.0	0.0
BXD03	0.0	0.0
BXD04	0.0	0.0
BXD05	0.0	0.0
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.0	0.0
CCcont	0.149	0.149
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.0	0.0
DS0c	0.0	0.0
GP01	0.0	0.0
GP02	0.0	0.0
GP0c	0.0	0.0
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.0	0.0
H37Rv_KO_CtpD	0.348	0.348
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	0.0	0.0
H37Rv_KO_MbtN	0.0	0.0
Trans05	0.0	0.0
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-0.593	-0.593
delta_Rv3594	0.532	0.532
delta_Rv3717	-0.174	-0.174
delta_Rv3811	0.187	0.187
delta_Rv0954	-0.178	-0.178
PonA1	0.819	0.819
EccD1_KO	0.414	0.414
EspI_KO	-0.394	-0.394
PE35_KO	0.368	0.368
PPE68_KO	1.113	1.113
glycerol2	-0.68	-0.68
lignocerate	-0.591	-0.591
oleate	-0.688	-0.688
phosphatidylcholine	-0.679	-0.679
acetate	-0.369	-0.369
glucAc	-0.36	-0.36
Rv0950ko	0.0	0.0
Rv1096ko	0.0	0.0
Rv3684ko	0.452	0.452
delta_otsA_trehalose	0.778	0.778