TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0335c/PE6:
none

Correlation of Rv0335c/PE6 with Rv0335c/PE6

Normalized LFCs for Rv0335c/PE6:
(description and provenance of datasets)

	Rv0335c/PE6	Rv0335c/PE6
Fe_supp_jason_reseq	0.0	0.0
low_pH_jason_reseq	1.79	1.79
NO_jason_reseq	0.0	0.0
B6_jason_reseq	4.224	4.224
MHCII_jason_reseq	2.241	2.241
Isoniazid02	0.0	0.0
Rifampicin4	0.0	0.0
Ethambutol3	0.0	0.0
Meropenem3	0.0	0.0
Vancomycin16	0.0	0.0
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	-0.178	-0.178
hypoxia_3wks	2.333	2.333
hypoxia_6wks	-1.539	-1.539
glycerol	1.328	1.328
cholesterol	-1.329	-1.329
AJ	-1.059	-1.059
Bibs02	2.029	2.029
Bibs02c	2.023	2.023
BL6	-2.447	-2.447
BL6a	-1.818	-1.818
BXD01	-2.548	-2.548
BXD010	-2.055	-2.055
BXD011	-1.442	-1.442
BXD03	-2.645	-2.645
BXD04	-2.419	-2.419
BXD05	-2.632	-2.632
BXD06	-2.478	-2.478
BXD07	-2.571	-2.571
BXD08	-2.601	-2.601
BXD09	-2.609	-2.609
CAST	-0.153	-0.153
CCcont	-2.773	-2.773
DS01	0.885	0.885
DS02	0.295	0.295
DS04	2.771	2.771
DS0c	-2.91	-2.91
GP01	-0.731	-0.731
GP02	-1.627	-1.627
GP0c	-0.593	-0.593
NOD	-2.887	-2.887
NZO	1.539	1.539
PWK	-1.584	-1.584
H37Rv_KO_CtpC	-0.867	-0.867
H37Rv_KO_CtpD	-2.477	-2.477
H37Rv_KO_Rv1272	-0.387	-0.387
H37Rv_KO_SugABC	-1.388	-1.388
H37Rv_KO_MbtN	-1.579	-1.579
Trans05	-2.556	-2.556
macrophage_unactivated	-5.003	-5.003
IL1	-4.292	-4.292
Rapamycin	-4.864	-4.864
Tcell	-3.258	-3.258
GMCSF	-4.185	-4.185
IFNab	-4.792	-4.792
IFNg	-4.236	-4.236
IFNg_GMCSF1	-1.203	-1.203
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-0.216	-0.216
delta_Rv3594	0.0	0.0
delta_Rv3717	0.0	0.0
delta_Rv3811	2.051	2.051
delta_Rv0954	2.109	2.109
PonA1	0.0	0.0
EccD1_KO	2.897	2.897
EspI_KO	4.446	4.446
PE35_KO	0.618	0.618
PPE68_KO	0.678	0.678
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	4.065	4.065
Rv1096ko	1.894	1.894
Rv3684ko	3.688	3.688
delta_otsA_trehalose	0.0	0.0