TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0322/udgA:
none

Correlation of Rv0322/udgA with Rv0322/udgA

Normalized LFCs for Rv0322/udgA:
(description and provenance of datasets)

	Rv0322/udgA	Rv0322/udgA
Fe_supp_jason_reseq	0.38	0.38
low_pH_jason_reseq	-0.386	-0.386
NO_jason_reseq	-0.606	-0.606
B6_jason_reseq	0.357	0.357
MHCII_jason_reseq	0.413	0.413
Isoniazid02	-0.153	-0.153
Rifampicin4	0.563	0.563
Ethambutol3	-0.102	-0.102
Meropenem3	0.803	0.803
Vancomycin16	0.552	0.552
Rv2680_day32	-0.465	-0.465
H37Rv_KO_MarP	0.432	0.432
hypoxia_3wks	-0.068	-0.068
hypoxia_6wks	-0.535	-0.535
glycerol	-0.353	-0.353
cholesterol	-0.484	-0.484
AJ	-0.356	-0.356
Bibs02	0.599	0.599
Bibs02c	0.036	0.036
BL6	0.465	0.465
BL6a	-0.453	-0.453
BXD01	-0.552	-0.552
BXD010	-0.366	-0.366
BXD011	-0.07	-0.07
BXD03	-0.537	-0.537
BXD04	-0.61	-0.61
BXD05	-0.57	-0.57
BXD06	-0.462	-0.462
BXD07	-0.702	-0.702
BXD08	-0.381	-0.381
BXD09	-0.202	-0.202
CAST	-0.042	-0.042
CCcont	-0.292	-0.292
DS01	0.163	0.163
DS02	0.186	0.186
DS04	0.183	0.183
DS0c	0.622	0.622
GP01	-0.837	-0.837
GP02	-0.086	-0.086
GP0c	-0.16	-0.16
NOD	0.472	0.472
NZO	-0.053	-0.053
PWK	-0.384	-0.384
H37Rv_KO_CtpC	-0.755	-0.755
H37Rv_KO_CtpD	-0.362	-0.362
H37Rv_KO_Rv1272	-0.635	-0.635
H37Rv_KO_SugABC	0.034	0.034
H37Rv_KO_MbtN	-0.569	-0.569
Trans05	0.101	0.101
macrophage_unactivated	0.325	0.325
IL1	0.727	0.727
Rapamycin	0.16	0.16
Tcell	0.495	0.495
GMCSF	0.607	0.607
IFNab	0.46	0.46
IFNg	-0.508	-0.508
IFNg_GMCSF1	0.324	0.324
Rv1432_day32	0.24	0.24
Rv1565c_day32	0.201	0.201
secA2_input	-0.283	-0.283
delta_Rv3594	-0.441	-0.441
delta_Rv3717	0.0	0.0
delta_Rv3811	-0.275	-0.275
delta_Rv0954	0.64	0.64
PonA1	0.078	0.078
EccD1_KO	0.122	0.122
EspI_KO	0.508	0.508
PE35_KO	0.268	0.268
PPE68_KO	0.515	0.515
glycerol2	-0.098	-0.098
lignocerate	0.371	0.371
oleate	-0.427	-0.427
phosphatidylcholine	-0.073	-0.073
acetate	0.846	0.846
glucAc	0.477	0.477
Rv0950ko	0.935	0.935
Rv1096ko	0.935	0.935
Rv3684ko	0.907	0.907
delta_otsA_trehalose	-0.302	-0.302