TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0193c/-:
none

Correlation of Rv0193c/- with Rv0193c/-

Normalized LFCs for Rv0193c/-:
(description and provenance of datasets)

	Rv0193c/-	Rv0193c/-
Fe_supp_jason_reseq	0.054	0.054
low_pH_jason_reseq	0.018	0.018
NO_jason_reseq	-0.2	-0.2
B6_jason_reseq	0.168	0.168
MHCII_jason_reseq	-0.185	-0.185
Isoniazid02	-0.845	-0.845
Rifampicin4	-0.295	-0.295
Ethambutol3	-0.531	-0.531
Meropenem3	-0.234	-0.234
Vancomycin16	-0.655	-0.655
Rv2680_day32	-0.771	-0.771
H37Rv_KO_MarP	0.33	0.33
hypoxia_3wks	0.251	0.251
hypoxia_6wks	0.775	0.775
glycerol	-0.777	-0.777
cholesterol	-0.496	-0.496
AJ	0.02	0.02
Bibs02	-0.338	-0.338
Bibs02c	0.359	0.359
BL6	-0.256	-0.256
BL6a	0.122	0.122
BXD01	-0.121	-0.121
BXD010	-0.649	-0.649
BXD011	-0.022	-0.022
BXD03	-0.622	-0.622
BXD04	-0.402	-0.402
BXD05	-0.255	-0.255
BXD06	-0.111	-0.111
BXD07	-0.372	-0.372
BXD08	-0.225	-0.225
BXD09	-0.231	-0.231
CAST	-0.12	-0.12
CCcont	-0.173	-0.173
DS01	-0.209	-0.209
DS02	-0.172	-0.172
DS04	0.689	0.689
DS0c	0.211	0.211
GP01	0.586	0.586
GP02	0.548	0.548
GP0c	0.268	0.268
NOD	0.13	0.13
NZO	-0.409	-0.409
PWK	0.159	0.159
H37Rv_KO_CtpC	0.255	0.255
H37Rv_KO_CtpD	0.737	0.737
H37Rv_KO_Rv1272	0.74	0.74
H37Rv_KO_SugABC	0.907	0.907
H37Rv_KO_MbtN	0.435	0.435
Trans05	0.336	0.336
macrophage_unactivated	-0.338	-0.338
IL1	-0.021	-0.021
Rapamycin	-0.15	-0.15
Tcell	-0.371	-0.371
GMCSF	0.396	0.396
IFNab	-0.647	-0.647
IFNg	0.126	0.126
IFNg_GMCSF1	-0.289	-0.289
Rv1432_day32	0.28	0.28
Rv1565c_day32	-0.284	-0.284
secA2_input	0.182	0.182
delta_Rv3594	-0.398	-0.398
delta_Rv3717	0.063	0.063
delta_Rv3811	0.007	0.007
delta_Rv0954	-0.222	-0.222
PonA1	0.046	0.046
EccD1_KO	-0.016	-0.016
EspI_KO	0.265	0.265
PE35_KO	-0.12	-0.12
PPE68_KO	-0.214	-0.214
glycerol2	0.251	0.251
lignocerate	0.169	0.169
oleate	0.335	0.335
phosphatidylcholine	-0.021	-0.021
acetate	0.025	0.025
glucAc	0.13	0.13
Rv0950ko	0.03	0.03
Rv1096ko	-0.501	-0.501
Rv3684ko	-0.413	-0.413
delta_otsA_trehalose	-0.876	-0.876