TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0151c/PE1:
none

Correlation of Rv0151c/PE1 with Rv0151c/PE1

Normalized LFCs for Rv0151c/PE1:
(description and provenance of datasets)

	Rv0151c/PE1	Rv0151c/PE1
Fe_supp_jason_reseq	0.232	0.232
low_pH_jason_reseq	-0.089	-0.089
NO_jason_reseq	-0.431	-0.431
B6_jason_reseq	0.306	0.306
MHCII_jason_reseq	0.103	0.103
Isoniazid02	-0.924	-0.924
Rifampicin4	-0.146	-0.146
Ethambutol3	-0.03	-0.03
Meropenem3	0.235	0.235
Vancomycin16	-0.464	-0.464
Rv2680_day32	0.515	0.515
H37Rv_KO_MarP	0.555	0.555
hypoxia_3wks	-0.104	-0.104
hypoxia_6wks	-0.01	-0.01
glycerol	-0.544	-0.544
cholesterol	0.427	0.427
AJ	0.185	0.185
Bibs02	-0.074	-0.074
Bibs02c	-0.042	-0.042
BL6	0.365	0.365
BL6a	0.201	0.201
BXD01	0.249	0.249
BXD010	0.519	0.519
BXD011	0.317	0.317
BXD03	0.047	0.047
BXD04	0.0	0.0
BXD05	0.136	0.136
BXD06	0.273	0.273
BXD07	0.265	0.265
BXD08	0.384	0.384
BXD09	0.337	0.337
CAST	0.133	0.133
CCcont	-0.13	-0.13
DS01	0.065	0.065
DS02	-0.217	-0.217
DS04	0.177	0.177
DS0c	-0.008	-0.008
GP01	0.729	0.729
GP02	0.093	0.093
GP0c	0.119	0.119
NOD	-0.244	-0.244
NZO	0.588	0.588
PWK	0.179	0.179
H37Rv_KO_CtpC	0.0	0.0
H37Rv_KO_CtpD	0.53	0.53
H37Rv_KO_Rv1272	0.403	0.403
H37Rv_KO_SugABC	0.555	0.555
H37Rv_KO_MbtN	0.187	0.187
Trans05	0.151	0.151
macrophage_unactivated	0.265	0.265
IL1	0.074	0.074
Rapamycin	0.184	0.184
Tcell	-0.134	-0.134
GMCSF	-0.164	-0.164
IFNab	0.06	0.06
IFNg	-0.11	-0.11
IFNg_GMCSF1	0.412	0.412
Rv1432_day32	0.712	0.712
Rv1565c_day32	-0.069	-0.069
secA2_input	-0.116	-0.116
delta_Rv3594	-0.156	-0.156
delta_Rv3717	-0.21	-0.21
delta_Rv3811	-0.059	-0.059
delta_Rv0954	-0.202	-0.202
PonA1	-0.305	-0.305
EccD1_KO	-0.579	-0.579
EspI_KO	-0.217	-0.217
PE35_KO	-0.359	-0.359
PPE68_KO	-0.362	-0.362
glycerol2	0.209	0.209
lignocerate	0.246	0.246
oleate	0.366	0.366
phosphatidylcholine	0.209	0.209
acetate	0.116	0.116
glucAc	0.203	0.203
Rv0950ko	0.054	0.054
Rv1096ko	-0.365	-0.365
Rv3684ko	-0.124	-0.124
delta_otsA_trehalose	-0.04	-0.04