TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0035/fadD34:
none

Correlation of Rv0035/fadD34 with Rv0035/fadD34

Normalized LFCs for Rv0035/fadD34:
(description and provenance of datasets)

	Rv0035/fadD34	Rv0035/fadD34
Fe_supp_jason_reseq	-0.546	-0.546
low_pH_jason_reseq	-0.713	-0.713
NO_jason_reseq	-0.32	-0.32
B6_jason_reseq	0.061	0.061
MHCII_jason_reseq	0.141	0.141
Isoniazid02	-0.048	-0.048
Rifampicin4	0.054	0.054
Ethambutol3	-0.073	-0.073
Meropenem3	-0.208	-0.208
Vancomycin16	0.186	0.186
Rv2680_day32	-0.152	-0.152
H37Rv_KO_MarP	0.14	0.14
hypoxia_3wks	0.263	0.263
hypoxia_6wks	0.075	0.075
glycerol	-0.492	-0.492
cholesterol	-0.345	-0.345
AJ	0.188	0.188
Bibs02	0.008	0.008
Bibs02c	0.017	0.017
BL6	-0.791	-0.791
BL6a	0.086	0.086
BXD01	-0.173	-0.173
BXD010	-0.069	-0.069
BXD011	-0.336	-0.336
BXD03	0.1	0.1
BXD04	-0.12	-0.12
BXD05	-0.235	-0.235
BXD06	-0.111	-0.111
BXD07	-0.517	-0.517
BXD08	-0.239	-0.239
BXD09	0.114	0.114
CAST	0.143	0.143
CCcont	-0.848	-0.848
DS01	0.103	0.103
DS02	0.874	0.874
DS04	-0.031	-0.031
DS0c	-0.08	-0.08
GP01	0.182	0.182
GP02	0.263	0.263
GP0c	0.139	0.139
NOD	0.098	0.098
NZO	0.228	0.228
PWK	0.173	0.173
H37Rv_KO_CtpC	-0.578	-0.578
H37Rv_KO_CtpD	0.055	0.055
H37Rv_KO_Rv1272	-0.2	-0.2
H37Rv_KO_SugABC	-0.287	-0.287
H37Rv_KO_MbtN	0.04	0.04
Trans05	0.135	0.135
macrophage_unactivated	-0.726	-0.726
IL1	-0.392	-0.392
Rapamycin	-0.362	-0.362
Tcell	-0.577	-0.577
GMCSF	-0.467	-0.467
IFNab	0.039	0.039
IFNg	0.241	0.241
IFNg_GMCSF1	-0.063	-0.063
Rv1432_day32	0.326	0.326
Rv1565c_day32	0.24	0.24
secA2_input	0.474	0.474
delta_Rv3594	-0.765	-0.765
delta_Rv3717	-0.478	-0.478
delta_Rv3811	-0.349	-0.349
delta_Rv0954	-0.047	-0.047
PonA1	-0.134	-0.134
EccD1_KO	0.401	0.401
EspI_KO	-0.257	-0.257
PE35_KO	0.096	0.096
PPE68_KO	0.291	0.291
glycerol2	-0.027	-0.027
lignocerate	-0.301	-0.301
oleate	0.228	0.228
phosphatidylcholine	-0.195	-0.195
acetate	-0.485	-0.485
glucAc	-0.81	-0.81
Rv0950ko	0.89	0.89
Rv1096ko	0.455	0.455
Rv3684ko	0.318	0.318
delta_otsA_trehalose	0.823	0.823