from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3920c/-

LFCtreatmentdescriptionclass of inhibitor

-0.197

Amikacinug/mL Amikacintranslation

-0.777

Cap5-10ug/mL Capreomycintranslation

-1.052

Rox10-50 ug/mL Roxithromycintranslation

0.731

SM2-5 ug/mL Streptomycintranslation

0.637

Tet5-10 ug/mL Tetracyclinetranslation

0.264

Rif0.2-5ug/mL Rifampicintranscription

-0.614

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.301

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.550

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.107

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.883

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.199

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.630

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-3.643

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.170

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.627

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.486

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.210

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-2.355

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.638

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.998

KCN5-20 ug/mL Potassium cyaniderespiration

-0.135

NaN30.2-2 mM Sodium aziderespiration

-0.116

Nigericin50 uM Nigericinrespiration

-0.208

TRC10-150 ug/mL Triclosanrespiration

-1.504

TRZ10-25 ug/mL Thioridazinerespiration

-0.764

Valinomycin0.5-10 uM Valinomycinrespiration

-0.109

ZnSO42 mM ZnSO4respiration

0.123

menadione6-10 ug/mL Menadionerespiration

0.562

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.161

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.847

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.278

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.619

NRP_1Non-replicating persistence stage 1dosRassociated

0.780

Amp0.2mg/mL AmpicillincellWall

0.105

Cephalexin20-100 ug/mL CephalexincellWall

0.130

Cerulenin0.32-5 ug/mL CerulenincellWall

0.562

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.386

EMB10-20 ug/mL EthambutolcellWall

0.380

Eta12-40 ug/mL EthionamidecellWall

0.861

INH0.2-0.4 ug/mL IsoniazidcellWall

0.377

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.415

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.170

BZA0.12 mg/mL BenzamidearomaticAmides

0.433

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.634

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.780

H2O24 mM hydrogen peroxideDNAdamaging

-0.182

Levo10 ug/mL LevofloxacinDNAdamaging

1.018

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.570

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.308

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.971

UVUV-irradiationDNAdamaging

-0.154

ARP41-4 ug/mL Antitubercular compound ARP4?

0.020

Antimycin12.5-50 ug/mL Antimycin A?

-0.017

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.184

PA_110-50 ug/mL Antitubercular compound PA-1?

0.090

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.593

PA8240.2-2 ug/mL PA-824?

-1.138

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.269

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.377

Verapamil50 uM Verapamil?

-0.253

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.099

methoxatin10-20 ug/mL Methoxatin?