from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3902c/-

LFCtreatmentdescriptionclass of inhibitor

0.782

Amikacinug/mL Amikacintranslation

0.311

Cap5-10ug/mL Capreomycintranslation

0.982

Rox10-50 ug/mL Roxithromycintranslation

-0.158

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

-0.725

Rif0.2-5ug/mL Rifampicintranscription

0.670

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.568

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.616

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.266

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.951

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.694

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.042

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.467

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.636

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.753

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.672

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.696

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.971

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.546

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.223

Nigericin50 uM Nigericinrespiration

0.126

TRC10-150 ug/mL Triclosanrespiration

-0.515

TRZ10-25 ug/mL Thioridazinerespiration

0.623

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.957

menadione6-10 ug/mL Menadionerespiration

-0.059

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.016

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.263

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.190

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.397

NRP_1Non-replicating persistence stage 1dosRassociated

-0.356

Amp0.2mg/mL AmpicillincellWall

-0.525

Cephalexin20-100 ug/mL CephalexincellWall

1.080

Cerulenin0.32-5 ug/mL CerulenincellWall

0.397

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.529

EMB10-20 ug/mL EthambutolcellWall

0.813

Eta12-40 ug/mL EthionamidecellWall

0.260

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.439

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.304

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.691

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.043

BZA0.12 mg/mL BenzamidearomaticAmides

0.315

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.514

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.817

H2O24 mM hydrogen peroxideDNAdamaging

-0.278

Levo10 ug/mL LevofloxacinDNAdamaging

0.301

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.075

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.000

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.445

UVUV-irradiationDNAdamaging

-0.851

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.249

Antimycin12.5-50 ug/mL Antimycin A?

-0.747

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.654

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.647

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.013

PA8240.2-2 ug/mL PA-824?

0.325

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.206

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.861

Verapamil50 uM Verapamil?

-1.013

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.139

methoxatin10-20 ug/mL Methoxatin?