from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3883c/mycP1

LFCtreatmentdescriptionclass of inhibitor

-0.760

Amikacinug/mL Amikacintranslation

-0.223

Cap5-10ug/mL Capreomycintranslation

0.696

Rox10-50 ug/mL Roxithromycintranslation

0.407

SM2-5 ug/mL Streptomycintranslation

-0.460

Tet5-10 ug/mL Tetracyclinetranslation

0.046

Rif0.2-5ug/mL Rifampicintranscription

0.607

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.395

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.126

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.795

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.371

Clofazimine10-13 ug/mL Clofaziminerespiration

0.317

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.520

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.630

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.054

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.140

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.538

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.070

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.034

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.658

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.599

KCN5-20 ug/mL Potassium cyaniderespiration

-0.205

NaN30.2-2 mM Sodium aziderespiration

0.765

Nigericin50 uM Nigericinrespiration

-1.422

TRC10-150 ug/mL Triclosanrespiration

0.655

TRZ10-25 ug/mL Thioridazinerespiration

0.972

Valinomycin0.5-10 uM Valinomycinrespiration

0.118

ZnSO42 mM ZnSO4respiration

0.530

menadione6-10 ug/mL Menadionerespiration

-0.023

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.716

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.226

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.451

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.364

NRP_1Non-replicating persistence stage 1dosRassociated

0.467

Amp0.2mg/mL AmpicillincellWall

0.610

Cephalexin20-100 ug/mL CephalexincellWall

0.585

Cerulenin0.32-5 ug/mL CerulenincellWall

0.116

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.405

EMB10-20 ug/mL EthambutolcellWall

0.624

Eta12-40 ug/mL EthionamidecellWall

0.769

INH0.2-0.4 ug/mL IsoniazidcellWall

0.386

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.060

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.023

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.486

BZA0.12 mg/mL BenzamidearomaticAmides

-1.228

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.807

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.413

H2O24 mM hydrogen peroxideDNAdamaging

0.365

Levo10 ug/mL LevofloxacinDNAdamaging

-0.220

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.036

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.299

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.305

UVUV-irradiationDNAdamaging

-0.968

ARP41-4 ug/mL Antitubercular compound ARP4?

0.299

Antimycin12.5-50 ug/mL Antimycin A?

0.142

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

1.216

PA_110-50 ug/mL Antitubercular compound PA-1?

0.372

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.285

PA8240.2-2 ug/mL PA-824?

0.025

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.619

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.860

Verapamil50 uM Verapamil?

0.920

mercaptoethanol2 mM 2-Mercaptoethanol?

0.059

methoxatin10-20 ug/mL Methoxatin?