from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3871/eccCb1

LFCtreatmentdescriptionclass of inhibitor

-0.709

Amikacinug/mL Amikacintranslation

-0.764

Cap5-10ug/mL Capreomycintranslation

-1.184

Rox10-50 ug/mL Roxithromycintranslation

-0.542

SM2-5 ug/mL Streptomycintranslation

-2.905

Tet5-10 ug/mL Tetracyclinetranslation

-0.520

Rif0.2-5ug/mL Rifampicintranscription

0.364

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.643

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.263

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.428

CPZ10-50 ug/mL Chlorpromazinerespiration

0.867

Clofazimine10-13 ug/mL Clofaziminerespiration

0.472

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.318

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

2.003

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.465

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.532

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.321

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.691

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.768

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.305

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

3.401

KCN5-20 ug/mL Potassium cyaniderespiration

0.608

NaN30.2-2 mM Sodium aziderespiration

0.290

Nigericin50 uM Nigericinrespiration

0.715

TRC10-150 ug/mL Triclosanrespiration

0.997

TRZ10-25 ug/mL Thioridazinerespiration

-0.849

Valinomycin0.5-10 uM Valinomycinrespiration

0.095

ZnSO42 mM ZnSO4respiration

0.090

menadione6-10 ug/mL Menadionerespiration

0.263

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.041

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.239

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.031

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.150

NRP_1Non-replicating persistence stage 1dosRassociated

-0.547

Amp0.2mg/mL AmpicillincellWall

-0.072

Cephalexin20-100 ug/mL CephalexincellWall

-0.215

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.022

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.532

EMB10-20 ug/mL EthambutolcellWall

0.109

Eta12-40 ug/mL EthionamidecellWall

0.006

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.194

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.187

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.104

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.271

BZA0.12 mg/mL BenzamidearomaticAmides

-0.258

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.392

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.989

H2O24 mM hydrogen peroxideDNAdamaging

-0.044

Levo10 ug/mL LevofloxacinDNAdamaging

-1.234

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.898

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.565

Oflox5-10 ug/mL OfloxacinDNAdamaging

-1.462

UVUV-irradiationDNAdamaging

0.347

ARP41-4 ug/mL Antitubercular compound ARP4?

0.718

Antimycin12.5-50 ug/mL Antimycin A?

0.164

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.220

PA_110-50 ug/mL Antitubercular compound PA-1?

0.048

PA_2110-50 ug/mL Antitubercular compound PA-21?

2.110

PA8240.2-2 ug/mL PA-824?

1.072

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.738

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.378

Verapamil50 uM Verapamil?

0.367

mercaptoethanol2 mM 2-Mercaptoethanol?

0.354

methoxatin10-20 ug/mL Methoxatin?