from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3846/sodA

LFCtreatmentdescriptionclass of inhibitor

-0.313

Amikacinug/mL Amikacintranslation

-0.149

Cap5-10ug/mL Capreomycintranslation

-1.130

Rox10-50 ug/mL Roxithromycintranslation

0.071

SM2-5 ug/mL Streptomycintranslation

-0.332

Tet5-10 ug/mL Tetracyclinetranslation

-0.541

Rif0.2-5ug/mL Rifampicintranscription

-0.133

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.857

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.460

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.370

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.600

Clofazimine10-13 ug/mL Clofaziminerespiration

0.263

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.492

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.404

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.208

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.333

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.091

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.129

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.902

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.188

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.334

KCN5-20 ug/mL Potassium cyaniderespiration

-0.049

NaN30.2-2 mM Sodium aziderespiration

0.925

Nigericin50 uM Nigericinrespiration

0.306

TRC10-150 ug/mL Triclosanrespiration

-0.686

TRZ10-25 ug/mL Thioridazinerespiration

-1.981

Valinomycin0.5-10 uM Valinomycinrespiration

0.419

ZnSO42 mM ZnSO4respiration

-0.289

menadione6-10 ug/mL Menadionerespiration

-0.996

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.004

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.763

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.449

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.310

NRP_1Non-replicating persistence stage 1dosRassociated

0.518

Amp0.2mg/mL AmpicillincellWall

0.734

Cephalexin20-100 ug/mL CephalexincellWall

0.431

Cerulenin0.32-5 ug/mL CerulenincellWall

0.634

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.429

EMB10-20 ug/mL EthambutolcellWall

0.393

Eta12-40 ug/mL EthionamidecellWall

-0.039

INH0.2-0.4 ug/mL IsoniazidcellWall

0.459

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.807

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.425

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.478

BZA0.12 mg/mL BenzamidearomaticAmides

-0.136

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.751

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.496

H2O24 mM hydrogen peroxideDNAdamaging

0.627

Levo10 ug/mL LevofloxacinDNAdamaging

1.043

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.398

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.028

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.578

UVUV-irradiationDNAdamaging

-1.546

ARP41-4 ug/mL Antitubercular compound ARP4?

0.586

Antimycin12.5-50 ug/mL Antimycin A?

0.203

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.167

PA_110-50 ug/mL Antitubercular compound PA-1?

0.231

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.846

PA8240.2-2 ug/mL PA-824?

-1.663

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.330

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.277

Verapamil50 uM Verapamil?

0.785

mercaptoethanol2 mM 2-Mercaptoethanol?

0.333

methoxatin10-20 ug/mL Methoxatin?