from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3842c/glpQ1

LFCtreatmentdescriptionclass of inhibitor

-0.419

Amikacinug/mL Amikacintranslation

-1.026

Cap5-10ug/mL Capreomycintranslation

-0.542

Rox10-50 ug/mL Roxithromycintranslation

-0.023

SM2-5 ug/mL Streptomycintranslation

-1.590

Tet5-10 ug/mL Tetracyclinetranslation

-0.520

Rif0.2-5ug/mL Rifampicintranscription

-0.900

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.015

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.997

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.780

CPZ10-50 ug/mL Chlorpromazinerespiration

0.849

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.115

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.576

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.462

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.375

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.144

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.468

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.641

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.569

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.200

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.981

KCN5-20 ug/mL Potassium cyaniderespiration

0.860

NaN30.2-2 mM Sodium aziderespiration

-0.981

Nigericin50 uM Nigericinrespiration

0.346

TRC10-150 ug/mL Triclosanrespiration

0.474

TRZ10-25 ug/mL Thioridazinerespiration

-1.691

Valinomycin0.5-10 uM Valinomycinrespiration

1.063

ZnSO42 mM ZnSO4respiration

-0.134

menadione6-10 ug/mL Menadionerespiration

0.205

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.641

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.538

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.016

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.583

NRP_1Non-replicating persistence stage 1dosRassociated

0.062

Amp0.2mg/mL AmpicillincellWall

0.184

Cephalexin20-100 ug/mL CephalexincellWall

-0.458

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.818

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.247

EMB10-20 ug/mL EthambutolcellWall

0.245

Eta12-40 ug/mL EthionamidecellWall

0.992

INH0.2-0.4 ug/mL IsoniazidcellWall

0.142

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.182

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.525

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

BZA0.12 mg/mL BenzamidearomaticAmides

-0.680

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.877

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.171

H2O24 mM hydrogen peroxideDNAdamaging

-0.422

Levo10 ug/mL LevofloxacinDNAdamaging

-0.162

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

3.846

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.007

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.201

UVUV-irradiationDNAdamaging

-0.203

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.681

Antimycin12.5-50 ug/mL Antimycin A?

-0.543

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.354

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.278

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.701

PA8240.2-2 ug/mL PA-824?

0.447

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.398

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.284

Verapamil50 uM Verapamil?

-0.663

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.790

methoxatin10-20 ug/mL Methoxatin?