from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3826/fadD23

LFCtreatmentdescriptionclass of inhibitor

-1.980

Amikacinug/mL Amikacintranslation

-0.474

Cap5-10ug/mL Capreomycintranslation

-1.431

Rox10-50 ug/mL Roxithromycintranslation

-0.506

SM2-5 ug/mL Streptomycintranslation

-1.508

Tet5-10 ug/mL Tetracyclinetranslation

-0.431

Rif0.2-5ug/mL Rifampicintranscription

0.239

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.676

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.390

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.134

CPZ10-50 ug/mL Chlorpromazinerespiration

0.017

Clofazimine10-13 ug/mL Clofaziminerespiration

0.199

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.328

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.158

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.242

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.534

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.020

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.981

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.313

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.046

KCN5-20 ug/mL Potassium cyaniderespiration

-0.144

NaN30.2-2 mM Sodium aziderespiration

1.181

Nigericin50 uM Nigericinrespiration

-0.801

TRC10-150 ug/mL Triclosanrespiration

-0.003

TRZ10-25 ug/mL Thioridazinerespiration

-1.349

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.601

menadione6-10 ug/mL Menadionerespiration

0.416

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.450

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.580

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.500

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.323

NRP_1Non-replicating persistence stage 1dosRassociated

0.534

Amp0.2mg/mL AmpicillincellWall

0.428

Cephalexin20-100 ug/mL CephalexincellWall

0.414

Cerulenin0.32-5 ug/mL CerulenincellWall

0.358

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.078

EMB10-20 ug/mL EthambutolcellWall

0.284

Eta12-40 ug/mL EthionamidecellWall

-0.208

INH0.2-0.4 ug/mL IsoniazidcellWall

1.460

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.651

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.503

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.955

BZA0.12 mg/mL BenzamidearomaticAmides

-0.503

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.557

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.273

H2O24 mM hydrogen peroxideDNAdamaging

0.283

Levo10 ug/mL LevofloxacinDNAdamaging

0.667

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

2.481

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.130

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.019

UVUV-irradiationDNAdamaging

-0.948

ARP41-4 ug/mL Antitubercular compound ARP4?

0.702

Antimycin12.5-50 ug/mL Antimycin A?

1.104

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.465

PA_110-50 ug/mL Antitubercular compound PA-1?

0.279

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.552

PA8240.2-2 ug/mL PA-824?

-1.507

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.301

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

1.334

Verapamil50 uM Verapamil?

0.935

mercaptoethanol2 mM 2-Mercaptoethanol?

0.872

methoxatin10-20 ug/mL Methoxatin?