from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3817/-

LFCtreatmentdescriptionclass of inhibitor

-0.359

Amikacinug/mL Amikacintranslation

0.532

Cap5-10ug/mL Capreomycintranslation

-0.065

Rox10-50 ug/mL Roxithromycintranslation

0.170

SM2-5 ug/mL Streptomycintranslation

2.024

Tet5-10 ug/mL Tetracyclinetranslation

0.878

Rif0.2-5ug/mL Rifampicintranscription

0.772

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.227

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.092

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.219

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.386

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.927

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.595

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.838

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.396

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.418

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.957

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.102

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.231

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.340

KCN5-20 ug/mL Potassium cyaniderespiration

2.081

NaN30.2-2 mM Sodium aziderespiration

1.497

Nigericin50 uM Nigericinrespiration

-0.239

TRC10-150 ug/mL Triclosanrespiration

-0.160

TRZ10-25 ug/mL Thioridazinerespiration

-0.413

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.095

menadione6-10 ug/mL Menadionerespiration

0.226

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.321

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.253

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.192

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.165

NRP_1Non-replicating persistence stage 1dosRassociated

-0.092

Amp0.2mg/mL AmpicillincellWall

0.400

Cephalexin20-100 ug/mL CephalexincellWall

0.756

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.495

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-1.027

EMB10-20 ug/mL EthambutolcellWall

0.184

Eta12-40 ug/mL EthionamidecellWall

0.086

INH0.2-0.4 ug/mL IsoniazidcellWall

0.882

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.197

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.136

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.866

BZA0.12 mg/mL BenzamidearomaticAmides

-0.805

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.570

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.409

H2O24 mM hydrogen peroxideDNAdamaging

0.326

Levo10 ug/mL LevofloxacinDNAdamaging

-0.492

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.083

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.268

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.623

UVUV-irradiationDNAdamaging

1.325

ARP41-4 ug/mL Antitubercular compound ARP4?

0.041

Antimycin12.5-50 ug/mL Antimycin A?

1.161

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.249

PA_110-50 ug/mL Antitubercular compound PA-1?

0.313

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.730

PA8240.2-2 ug/mL PA-824?

0.519

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.278

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

1.157

Verapamil50 uM Verapamil?

0.506

mercaptoethanol2 mM 2-Mercaptoethanol?

0.923

methoxatin10-20 ug/mL Methoxatin?