from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3809c/glf

LFCtreatmentdescriptionclass of inhibitor

0.754

Amikacinug/mL Amikacintranslation

0.421

Cap5-10ug/mL Capreomycintranslation

0.376

Rox10-50 ug/mL Roxithromycintranslation

0.204

SM2-5 ug/mL Streptomycintranslation

0.947

Tet5-10 ug/mL Tetracyclinetranslation

1.570

Rif0.2-5ug/mL Rifampicintranscription

2.310

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.349

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.756

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.061

CPZ10-50 ug/mL Chlorpromazinerespiration

0.882

Clofazimine10-13 ug/mL Clofaziminerespiration

0.225

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.049

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.023

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.723

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.158

Econazole10-24 ug/mL Econazole (azole drug)respiration

-2.614

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.183

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.467

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.002

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

2.224

KCN5-20 ug/mL Potassium cyaniderespiration

-0.383

NaN30.2-2 mM Sodium aziderespiration

0.624

Nigericin50 uM Nigericinrespiration

0.387

TRC10-150 ug/mL Triclosanrespiration

-0.276

TRZ10-25 ug/mL Thioridazinerespiration

0.137

Valinomycin0.5-10 uM Valinomycinrespiration

1.550

ZnSO42 mM ZnSO4respiration

-0.205

menadione6-10 ug/mL Menadionerespiration

0.280

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.265

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.646

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.352

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.668

NRP_1Non-replicating persistence stage 1dosRassociated

-0.380

Amp0.2mg/mL AmpicillincellWall

0.076

Cephalexin20-100 ug/mL CephalexincellWall

0.351

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.151

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.240

EMB10-20 ug/mL EthambutolcellWall

-0.457

Eta12-40 ug/mL EthionamidecellWall

-0.391

INH0.2-0.4 ug/mL IsoniazidcellWall

0.233

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.203

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.133

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.145

BZA0.12 mg/mL BenzamidearomaticAmides

-0.350

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.861

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-1.080

H2O24 mM hydrogen peroxideDNAdamaging

0.715

Levo10 ug/mL LevofloxacinDNAdamaging

-1.150

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

2.505

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.850

Oflox5-10 ug/mL OfloxacinDNAdamaging

-1.338

UVUV-irradiationDNAdamaging

-0.938

ARP41-4 ug/mL Antitubercular compound ARP4?

0.314

Antimycin12.5-50 ug/mL Antimycin A?

1.036

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.240

PA_110-50 ug/mL Antitubercular compound PA-1?

0.061

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.920

PA8240.2-2 ug/mL PA-824?

-0.021

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.235

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.953

Verapamil50 uM Verapamil?

0.026

mercaptoethanol2 mM 2-Mercaptoethanol?

1.277

methoxatin10-20 ug/mL Methoxatin?