from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3806c/ubiA

LFCtreatmentdescriptionclass of inhibitor

-1.955

Amikacinug/mL Amikacintranslation

-0.507

Cap5-10ug/mL Capreomycintranslation

0.069

Rox10-50 ug/mL Roxithromycintranslation

-0.148

SM2-5 ug/mL Streptomycintranslation

0.150

Tet5-10 ug/mL Tetracyclinetranslation

-0.050

Rif0.2-5ug/mL Rifampicintranscription

0.078

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.382

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.553

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.402

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.711

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.066

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.040

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.894

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.879

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.108

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.356

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.538

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.547

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.127

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.022

KCN5-20 ug/mL Potassium cyaniderespiration

-0.151

NaN30.2-2 mM Sodium aziderespiration

-0.306

Nigericin50 uM Nigericinrespiration

-0.620

TRC10-150 ug/mL Triclosanrespiration

-1.457

TRZ10-25 ug/mL Thioridazinerespiration

-1.745

Valinomycin0.5-10 uM Valinomycinrespiration

0.451

ZnSO42 mM ZnSO4respiration

-0.629

menadione6-10 ug/mL Menadionerespiration

0.545

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.322

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.626

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.064

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.268

NRP_1Non-replicating persistence stage 1dosRassociated

0.690

Amp0.2mg/mL AmpicillincellWall

0.490

Cephalexin20-100 ug/mL CephalexincellWall

0.280

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.010

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.170

EMB10-20 ug/mL EthambutolcellWall

0.382

Eta12-40 ug/mL EthionamidecellWall

0.926

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.079

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.075

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.295

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.459

BZA0.12 mg/mL BenzamidearomaticAmides

0.600

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.376

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.013

H2O24 mM hydrogen peroxideDNAdamaging

0.409

Levo10 ug/mL LevofloxacinDNAdamaging

0.498

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.016

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.283

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.016

UVUV-irradiationDNAdamaging

-1.129

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.114

Antimycin12.5-50 ug/mL Antimycin A?

0.053

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.008

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.119

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.592

PA8240.2-2 ug/mL PA-824?

0.602

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.698

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.207

Verapamil50 uM Verapamil?

-0.254

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.055

methoxatin10-20 ug/mL Methoxatin?