from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3803c/fbpD

LFCtreatmentdescriptionclass of inhibitor

2.132

Amikacinug/mL Amikacintranslation

1.044

Cap5-10ug/mL Capreomycintranslation

2.109

Rox10-50 ug/mL Roxithromycintranslation

0.842

SM2-5 ug/mL Streptomycintranslation

2.439

Tet5-10 ug/mL Tetracyclinetranslation

0.715

Rif0.2-5ug/mL Rifampicintranscription

0.427

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.181

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.977

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-1.160

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.178

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.271

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.888

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.825

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.208

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.308

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.104

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.572

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.728

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.311

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.793

KCN5-20 ug/mL Potassium cyaniderespiration

-0.805

NaN30.2-2 mM Sodium aziderespiration

0.823

Nigericin50 uM Nigericinrespiration

-0.909

TRC10-150 ug/mL Triclosanrespiration

-1.209

TRZ10-25 ug/mL Thioridazinerespiration

-0.384

Valinomycin0.5-10 uM Valinomycinrespiration

0.509

ZnSO42 mM ZnSO4respiration

0.077

menadione6-10 ug/mL Menadionerespiration

-0.012

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.175

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.252

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.450

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.281

NRP_1Non-replicating persistence stage 1dosRassociated

0.524

Amp0.2mg/mL AmpicillincellWall

0.148

Cephalexin20-100 ug/mL CephalexincellWall

0.159

Cerulenin0.32-5 ug/mL CerulenincellWall

0.373

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.539

EMB10-20 ug/mL EthambutolcellWall

0.732

Eta12-40 ug/mL EthionamidecellWall

1.099

INH0.2-0.4 ug/mL IsoniazidcellWall

0.823

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.105

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.428

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.107

BZA0.12 mg/mL BenzamidearomaticAmides

0.220

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.432

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.509

H2O24 mM hydrogen peroxideDNAdamaging

0.071

Levo10 ug/mL LevofloxacinDNAdamaging

0.491

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.787

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.709

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.599

UVUV-irradiationDNAdamaging

-1.155

ARP41-4 ug/mL Antitubercular compound ARP4?

0.493

Antimycin12.5-50 ug/mL Antimycin A?

0.337

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.390

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.345

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.263

PA8240.2-2 ug/mL PA-824?

-1.078

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.172

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.023

Verapamil50 uM Verapamil?

0.547

mercaptoethanol2 mM 2-Mercaptoethanol?

0.192

methoxatin10-20 ug/mL Methoxatin?