from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3802c/-

LFCtreatmentdescriptionclass of inhibitor

-0.500

Amikacinug/mL Amikacintranslation

-0.027

Cap5-10ug/mL Capreomycintranslation

-0.085

Rox10-50 ug/mL Roxithromycintranslation

0.072

SM2-5 ug/mL Streptomycintranslation

-0.001

Tet5-10 ug/mL Tetracyclinetranslation

-1.920

Rif0.2-5ug/mL Rifampicintranscription

-1.114

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.344

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.812

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.574

CPZ10-50 ug/mL Chlorpromazinerespiration

0.806

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.911

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.651

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.413

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.124

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.283

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.535

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

2.360

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.637

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.710

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.729

KCN5-20 ug/mL Potassium cyaniderespiration

0.194

NaN30.2-2 mM Sodium aziderespiration

-0.161

Nigericin50 uM Nigericinrespiration

-0.515

TRC10-150 ug/mL Triclosanrespiration

1.523

TRZ10-25 ug/mL Thioridazinerespiration

1.093

Valinomycin0.5-10 uM Valinomycinrespiration

0.832

ZnSO42 mM ZnSO4respiration

1.102

menadione6-10 ug/mL Menadionerespiration

-0.040

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.170

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.136

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.163

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.652

NRP_1Non-replicating persistence stage 1dosRassociated

0.325

Amp0.2mg/mL AmpicillincellWall

-0.083

Cephalexin20-100 ug/mL CephalexincellWall

0.385

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.625

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.279

EMB10-20 ug/mL EthambutolcellWall

-0.015

Eta12-40 ug/mL EthionamidecellWall

-0.121

INH0.2-0.4 ug/mL IsoniazidcellWall

0.322

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.857

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.048

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.002

BZA0.12 mg/mL BenzamidearomaticAmides

-0.090

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.504

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.753

H2O24 mM hydrogen peroxideDNAdamaging

-0.375

Levo10 ug/mL LevofloxacinDNAdamaging

-0.500

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.140

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.013

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.519

UVUV-irradiationDNAdamaging

0.271

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.797

Antimycin12.5-50 ug/mL Antimycin A?

-0.399

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.874

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.864

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.368

PA8240.2-2 ug/mL PA-824?

0.796

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.184

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.301

Verapamil50 uM Verapamil?

-0.389

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.284

methoxatin10-20 ug/mL Methoxatin?