from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3801c/fadD32

LFCtreatmentdescriptionclass of inhibitor

-0.951

Amikacinug/mL Amikacintranslation

-0.992

Cap5-10ug/mL Capreomycintranslation

-1.731

Rox10-50 ug/mL Roxithromycintranslation

-0.062

SM2-5 ug/mL Streptomycintranslation

-1.886

Tet5-10 ug/mL Tetracyclinetranslation

-1.332

Rif0.2-5ug/mL Rifampicintranscription

-0.515

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.426

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.677

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.255

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.200

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.152

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.382

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.563

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.375

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.292

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.541

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.334

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.755

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.787

KCN5-20 ug/mL Potassium cyaniderespiration

-0.581

NaN30.2-2 mM Sodium aziderespiration

0.323

Nigericin50 uM Nigericinrespiration

-1.895

TRC10-150 ug/mL Triclosanrespiration

-0.646

TRZ10-25 ug/mL Thioridazinerespiration

1.269

Valinomycin0.5-10 uM Valinomycinrespiration

-0.117

ZnSO42 mM ZnSO4respiration

0.977

menadione6-10 ug/mL Menadionerespiration

0.018

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.256

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.311

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.517

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.762

NRP_1Non-replicating persistence stage 1dosRassociated

0.193

Amp0.2mg/mL AmpicillincellWall

0.019

Cephalexin20-100 ug/mL CephalexincellWall

1.615

Cerulenin0.32-5 ug/mL CerulenincellWall

0.589

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.270

EMB10-20 ug/mL EthambutolcellWall

1.548

Eta12-40 ug/mL EthionamidecellWall

1.544

INH0.2-0.4 ug/mL IsoniazidcellWall

1.539

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.142

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.174

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.345

BZA0.12 mg/mL BenzamidearomaticAmides

0.113

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.357

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.027

H2O24 mM hydrogen peroxideDNAdamaging

-0.587

Levo10 ug/mL LevofloxacinDNAdamaging

0.381

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.393

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.420

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.322

UVUV-irradiationDNAdamaging

-1.098

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.053

Antimycin12.5-50 ug/mL Antimycin A?

0.122

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.122

PA_110-50 ug/mL Antitubercular compound PA-1?

0.406

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.521

PA8240.2-2 ug/mL PA-824?

-0.513

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.555

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.196

Verapamil50 uM Verapamil?

0.086

mercaptoethanol2 mM 2-Mercaptoethanol?

0.099

methoxatin10-20 ug/mL Methoxatin?