from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3782/glfT1

LFCtreatmentdescriptionclass of inhibitor

-0.752

Amikacinug/mL Amikacintranslation

0.491

Cap5-10ug/mL Capreomycintranslation

0.550

Rox10-50 ug/mL Roxithromycintranslation

-0.618

SM2-5 ug/mL Streptomycintranslation

0.729

Tet5-10 ug/mL Tetracyclinetranslation

-1.484

Rif0.2-5ug/mL Rifampicintranscription

-0.802

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.455

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-3.217

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.691

CPZ10-50 ug/mL Chlorpromazinerespiration

0.318

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.011

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.207

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.821

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.140

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.412

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.569

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.161

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.347

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.633

KCN5-20 ug/mL Potassium cyaniderespiration

-0.182

NaN30.2-2 mM Sodium aziderespiration

-0.182

Nigericin50 uM Nigericinrespiration

-2.022

TRC10-150 ug/mL Triclosanrespiration

-1.114

TRZ10-25 ug/mL Thioridazinerespiration

0.134

Valinomycin0.5-10 uM Valinomycinrespiration

1.261

ZnSO42 mM ZnSO4respiration

0.290

menadione6-10 ug/mL Menadionerespiration

0.182

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.555

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.126

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.266

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.839

NRP_1Non-replicating persistence stage 1dosRassociated

0.810

Amp0.2mg/mL AmpicillincellWall

0.451

Cephalexin20-100 ug/mL CephalexincellWall

0.224

Cerulenin0.32-5 ug/mL CerulenincellWall

0.055

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.164

EMB10-20 ug/mL EthambutolcellWall

0.407

Eta12-40 ug/mL EthionamidecellWall

0.513

INH0.2-0.4 ug/mL IsoniazidcellWall

0.133

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.709

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.765

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.388

BZA0.12 mg/mL BenzamidearomaticAmides

-0.018

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.050

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.440

H2O24 mM hydrogen peroxideDNAdamaging

-0.148

Levo10 ug/mL LevofloxacinDNAdamaging

0.603

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.187

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.217

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.303

UVUV-irradiationDNAdamaging

-1.217

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.402

Antimycin12.5-50 ug/mL Antimycin A?

0.579

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.318

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.294

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.851

PA8240.2-2 ug/mL PA-824?

0.589

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.228

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

1.054

Verapamil50 uM Verapamil?

0.665

mercaptoethanol2 mM 2-Mercaptoethanol?

0.418

methoxatin10-20 ug/mL Methoxatin?